Pseudomonas aeruginosa PAO1, PA1446 (fliP)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1446
Name
fliP
Replicon chromosome
Genomic location 1574475 - 1575242 (+ strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250137.1
GI 15596643
Affymetrix PA1446_fliP_at
Entrez 881863
GenBank AAG04835.1
INSDC AAA79756.1
NCBI Locus Tag PA1446
protein_id(GenBank) gb|AAG04835.1|AE004574_6|gnl|PseudoCAP|PA1446
TIGR NTL03PA01447
UniParc UPI000012A9E1
UniProtKB Acc Q51468
UniProtKB ID FLIP_PSEAE
UniRef100 UniRef100_Q51468
UniRef50 UniRef50_Q51468
UniRef90 UniRef90_Q51468

Product

Feature Type CDS
Coding Frame 1
Product Name
flagellar biosynthetic protein FliP
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.04
Kyte-Doolittle Hydrophobicity Value 0.941
Molecular Weight (kDa) 27.6
Isoelectric Point (pI) 5.11

Subcellular localization

Individual Mappings
Localization Confidence PMID
Flagellar
Note: This is based on PSORTb V3.0 secondary localization prediction
Class 3
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0273
Category Flagella
Evidence
Host Organism
Notes
Reference 14617143

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 325 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001363 (539 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1446
Search term: fliP

Human Homologs

References

Components of the Salmonella flagellar export apparatus and classification of export substrates.
Minamino T, Macnab RM
J Bacteriol 1999 Mar;181(5):1388-94
PubMed ID: 10049367
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295