Pseudomonas aeruginosa PAO1, PA1669 (icmF2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1669
Name
icmF2
Replicon chromosome
Genomic location 1819074 - 1822601 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_250360.1
GI 15596866
Affymetrix PA1669_at
Entrez 882077
GenBank AAG05058.1
INSDC AAG05058.1
NCBI Locus Tag PA1669
protein_id(GenBank) gb|AAG05058.1|AE004594_10|gnl|PseudoCAP|PA1669
TIGR NTL03PA01670
UniParc UPI00000C543B
UniProtKB Acc Q9I356
UniProtKB ID Q9I356_PSEAE
UniRef100 UniRef100_Q9I356
UniRef50 UniRef50_G8Q735
UniRef90 UniRef90_Q9I356

Product

Feature Type CDS
Coding Frame 1
Product Name
IcmF2
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 16.62
Kyte-Doolittle Hydrophobicity Value -0.301
Molecular Weight (kDa) 133.0
Isoelectric Point (pI) 9.55

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 104 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000076 (865 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1669
Search term: icmF2
Search term: IcmF2

Human Homologs

References

The Legionella pneumophila icmGCDJBF genes are required for killing of human macrophages.
Purcell M, Shuman HA
Infect Immun 1998 May;66(5):2245-55
PubMed ID: 9573114