Pseudomonas aeruginosa PAO1, PA4447 (hisC1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA4447
Name
hisC1
Synonym: his8
Replicon chromosome
Genomic location 4981046 - 4982101 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253137.1
GI 15599643
Affymetrix PA4447_hisC1_at
Entrez 880991
GenBank AAG07835.1
INSDC AAG07835.1
NCBI Locus Tag PA4447
protein_id(GenBank) gb|AAG07835.1|AE004859_4|gnl|PseudoCAP|PA4447
TIGR NTL03PA04448
UniParc UPI000012C705
UniProtKB Acc Q9HVX0
UniProtKB ID HIS81_PSEAE
UniRef100 UniRef100_Q9HVX0
UniRef50 UniRef50_Q9HVX0
UniRef90 UniRef90_Q9HVX0

Product

Feature Type CDS
Coding Frame 1
Product Name
histidinol-phosphate aminotransferase
Product Name Confidence: Class 2
Synonyms imidazole acetol-phosphate transaminase
Evidence for Translation
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.69
Kyte-Doolittle Hydrophobicity Value -0.056
Molecular Weight (kDa) 38.7
Isoelectric Point (pI) 6.00

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 617 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004036 (552 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4447
Search term: hisC1

References

Structure and function of the Salmonella typhimurium and Escherichia coli K-12 histidine operons.
Carlomagno MS, Chiariotti L, Alifano P, Nappo AG, Bruni CB
J Mol Biol 1988 Oct 5;203(3):585-606
PubMed ID: 3062174
Histidine biosynthesis genes in Lactococcus lactis subsp. lactis.
Delorme C, Ehrlich SD, Renault P
J Bacteriol 1992 Oct;174(20):6571-9
PubMed ID: 1400209
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994