Pseudomonas aeruginosa PAO1, PA4448 (hisD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA4448
Name
hisD
Synonym: hisX
Replicon chromosome
Genomic location 4982104 - 4983426 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253138.1
GI 15599644
Affymetrix PA4448_hisD_at
Entrez 880992
GenBank AAG07836.1
INSDC AAG07836.1
NCBI Locus Tag PA4448
protein_id(GenBank) gb|AAG07836.1|AE004859_5|gnl|PseudoCAP|PA4448
TIGR NTL03PA04449
UniParc UPI000012C8E0
UniProtKB Acc Q9HVW9
UniProtKB ID HISX_PSEAE
UniRef100 UniRef100_Q9HVW9
UniRef50 UniRef50_Q606Q2
UniRef90 UniRef90_Q9HVW9

Product

Feature Type CDS
Coding Frame 1
Product Name
histidinol dehydrogenase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -13.97
Kyte-Doolittle Hydrophobicity Value 0.008
Molecular Weight (kDa) 47.2
Isoelectric Point (pI) 4.85

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 580 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004037 (553 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4448
Search term: hisD

References

Structural and physiological studies of the Escherichia coli histidine operon inserted into plasmid vectors.
Bruni CB, Musti AM, Frunzio R, Blasi F
J Bacteriol 1980 Apr;142(1):32-42
PubMed ID: 6246067
Structure and function of the Salmonella typhimurium and Escherichia coli K-12 histidine operons.
Carlomagno MS, Chiariotti L, Alifano P, Nappo AG, Bruni CB
J Mol Biol 1988 Oct 5;203(3):585-606
PubMed ID: 3062174
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994