Pseudomonas aeruginosa PAO1, PA4459 (lptC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA4459
Name
lptC
Synonym: yrbK
Replicon chromosome
Genomic location 4990833 - 4991405 (+ strand)
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253149.1
GI 15599655
Affymetrix PA4459_at
Entrez 881006
GenBank AAG07847.1
INSDC AAG07847.1
NCBI Locus Tag PA4459
protein_id(GenBank) gb|AAG07847.1|AE004860_3|gnl|PseudoCAP|PA4459
TIGR NTL03PA04460
UniParc UPI00000C5D1E
UniProtKB Acc Q9HVV8
UniProtKB ID Q9HVV8_PSEAE
UniRef100 UniRef100_W0Z0N0
UniRef50 UniRef50_Q87WU3
UniRef90 UniRef90_A6VBD3

Product

Feature Type CDS
Coding Frame 1
Product Name
Lipopolysaccharide export system protein LptC
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -0.81
Kyte-Doolittle Hydrophobicity Value -0.357
Molecular Weight (kDa) 21.4
Isoelectric Point (pI) 6.69

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 54 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004048 (553 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4459
Search term: lptC

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Cytoplasmic ATP hydrolysis powers transport of lipopolysaccharide across the periplasm in E. coli.
Okuda S, Freinkman E, Kahne D
Science 2012 Nov;338(6111):1214-7
PubMed ID: 23138981