Pseudomonas aeruginosa PAO1, PA5394 (cls)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA5394
Name
cls
Replicon chromosome
Genomic location 6071912 - 6073384 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_254081.1
GI 15600587
Affymetrix PA5394_cls_at
Entrez 883132
GenBank AAG08779.1
INSDC AAG08779.1
NCBI Locus Tag PA5394
protein_id(GenBank) gb|AAG08779.1|AE004952_1|gnl|PseudoCAP|PA5394
TIGR NTL03PA05395
UniParc UPI00000C5FDF
UniProtKB Acc Q9HTH0
UniProtKB ID CLSA_PSEAE
UniRef100 UniRef100_B7V5T6
UniRef50 UniRef50_Q4K3D9
UniRef90 UniRef90_B7V5T6

Product

Feature Type CDS
Coding Frame 1
Product Name
cardiolipin synthase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 2.78
Kyte-Doolittle Hydrophobicity Value 0.092
Molecular Weight (kDa) 54.6
Isoelectric Point (pI) 7.70

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 374 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004951 (524 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5394
Search term: cls

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Amplification and substantial purification of cardiolipin synthase of Escherichia coli.
Hiraoka S, Nukui K, Uetake N, Ohta A, Shibuya I
J Biochem 1991 Sep;110(3):443-9
PubMed ID: 1663113
Cloning of the Bacillus firmus OF4 cls gene and characterization of its gene product.
Guo D, Tropp BE
Biochim. Biophys. Acta 1998 Jan;1389(1):34-42
PubMed ID: 9443601