Pseudomonas aeruginosa PAO1, PA5436

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA5436
Name
Replicon chromosome
Genomic location 6118332 - 6119747 (- strand)
Transposon Mutants 6 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_254123.1
GI 15600629
Affymetrix PA5436_at
Entrez 877877
GenBank AAG08821.1
INSDC AAG08821.1
NCBI Locus Tag PA5436
protein_id(GenBank) gb|AAG08821.1|AE004956_5|gnl|PseudoCAP|PA5436
TIGR NTL03PA05437
UniParc UPI00000C6005
UniProtKB Acc Q9HTD0
UniProtKB ID Q9HTD0_PSEAE
UniRef100 UniRef100_A0A069Q656
UniRef50 UniRef50_P49787
UniRef90 UniRef90_A0A069Q656

Product

Feature Type CDS
Coding Frame 1
Product Name
probable biotin carboxylase subunit of a transcarboxylase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -2.58
Kyte-Doolittle Hydrophobicity Value -0.176
Molecular Weight (kDa) 51.8
Isoelectric Point (pI) 6.59

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 1
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 631 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004986 (552 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5436

Human Homologs

Ensembl 97, assembly GRCh38.p12
pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:8636]
E-value: 3.1e-121
Percent Identity: 47.9

Human Homologs

Ensembl 97, assembly GRCh38.p12
pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:8636]
E-value: 3.1e-121
Percent Identity: 47.9

Human Homologs

Ensembl 97, assembly GRCh38.p12
pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:8636]
E-value: 3.1e-121
Percent Identity: 47.9

Human Homologs

Ensembl 97, assembly GRCh38.p12
pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:8636]
E-value: 3.1e-121
Percent Identity: 47.9

Human Homologs

Ensembl 97, assembly GRCh38.p12
pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:8636]
E-value: 3.1e-121
Percent Identity: 47.9

Human Homologs

Ensembl 97, assembly GRCh38.p12
pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:8636]
E-value: 3.1e-121
Percent Identity: 47.9

Human Homologs

Ensembl 97, assembly GRCh38.p12
pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:8636]
E-value: 3.1e-121
Percent Identity: 47.9

Human Homologs

Ensembl 97, assembly GRCh38.p12
pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:8636]
E-value: 3.1e-121
Percent Identity: 47.9

References

The genes encoding the biotin carboxyl carrier protein and biotin carboxylase subunits of Bacillus subtilis acetyl coenzyme A carboxylase, the first enzyme of fatty acid synthesis.
Marini P, Li SJ, Gardiol D, Cronan JE, de Mendoza D
J. Bacteriol. 1995 Dec;177(23):7003-6
PubMed ID: 7592499
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994