Pseudomonas aeruginosa PAO1, PA5443 (uvrD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA5443
Name
uvrD
Synonym: rad
Synonym: pdeB
Synonym: mutU
Synonym: recL
Replicon chromosome
Genomic location 6131088 - 6133274 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_254130.1
GI 15600636
Affymetrix PA5443_uvrD_at
Entrez 877766
GenBank AAG08828.1
INSDC AAG08828.1
NCBI Locus Tag PA5443
protein_id(GenBank) gb|AAG08828.1|AE004957_3|gnl|PseudoCAP|PA5443
TIGR NTL03PA05444
UniParc UPI00000C4ECE
UniProtKB Acc G3XD04
UniProtKB ID G3XD04_PSEAE
UniRef100 UniRef100_G3XD04
UniRef50 UniRef50_P03018
UniRef90 UniRef90_G3XD04

Product

Feature Type CDS
Coding Frame 1
Product Name
UvrD helicase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -13.64
Kyte-Doolittle Hydrophobicity Value -0.283
Molecular Weight (kDa) 81.5
Isoelectric Point (pI) 5.67

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 640 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004994 (551 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5443
Search term: uvrD
Search term: UvrD helicase

References

Determination of the initiation sites of transcription and translation of the uvrD gene of Escherichia coli.
Yamamoto Y, Ogawa T, Shinagawa H, Nakayama T, Matsuo H, Ogawa H
J Biochem 1986 Jun;99(6):1579-90
PubMed ID: 2943729
Characterization of DNA helicase II from a uvrD252 mutant of Escherichia coli.
Washburn BK, Kushner SR
J. Bacteriol. 1993 Jan;175(2):341-50
PubMed ID: 8419285
Pf Filamentous Phage Requires UvrD for Replication in Pseudomonas aeruginosa.
Martínez E, Campos-Gómez J
mSphere 2016 Jan-Feb;1(1)
PubMed ID: 27303696