Pseudomonas aeruginosa PAO1, PA5483 (algB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA5483
Name
algB
Replicon chromosome
Genomic location 6173348 - 6174697 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_254170.1
GI 15600676
Affymetrix PA5483_algB_at
Entrez 877696
GenBank AAG08868.1
INSDC AAG08868.1
NCBI Locus Tag PA5483
protein_id(GenBank) gb|AAG08868.1|AE004961_3|gnl|PseudoCAP|PA5483
TIGR NTL03PA05484
UniParc UPI0000125848
UniProtKB Acc P23747
UniProtKB ID ALGB_PSEAE
UniRef100 UniRef100_P23747
UniRef50 UniRef50_P23747
UniRef90 UniRef90_P23747

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component response regulator AlgB
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -8.68
Kyte-Doolittle Hydrophobicity Value -0.194
Molecular Weight (kDa) 49.3
Isoelectric Point (pI) 5.16

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 619 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG005023 (548 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5483
Search term: algB

References

Pseudomonas aeruginosa AlgB, which modulates the expression of alginate, is a member of the NtrC subclass of prokaryotic regulators.
Goldberg JB, Dahnke T
Mol Microbiol 1992 Jan;6(1):59-66
PubMed ID: 1738315
The Pseudomonas aeruginosa sensor kinase KinB negatively controls alginate production through AlgW-dependent MucA proteolysis.
Damron FH, Qiu D, Yu HD
J. Bacteriol. 2009 Apr;191(7):2285-95
PubMed ID: 19168621