Pseudomonas aeruginosa PAO1, PA5499 (zur)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA5499
Name
zur
Synonym: np20
Replicon chromosome
Genomic location 6192179 - 6192682 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_254186.1
GI 15600692
Affymetrix PA5499_np20_at
DNASU PaCD00008369
Entrez 878913
GenBank AAG08884.1
INSDC AAG08884.1
NCBI Locus Tag PA5499
protein_id(GenBank) gb|AAG08884.1|AE004962_8|gnl|PseudoCAP|PA5499
TIGR NTL03PA05500
UniParc UPI00000C603A
UniProtKB Acc Q9HT74
UniProtKB ID Q9HT74_PSEAE
UniRef100 UniRef100_W0Z244
UniRef50 UniRef50_B6IRE0
UniRef90 UniRef90_A6VEX6

Product

Feature Type CDS
Coding Frame 1
Product Name
zinc uptake regulator, Zur
Product Name Confidence: Class 1
Synonyms transcriptional regulator np20
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -0.57
Kyte-Doolittle Hydrophobicity Value -0.111
Molecular Weight (kDa) 18.2
Isoelectric Point (pI) 6.85

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 289 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG005038 (555 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5499
Search term: zur

References

Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress.
Topper JN, Cai J, Falb D, Gimbrone MA
Proc. Natl. Acad. Sci. U.S.A. 1996 Sep;93(19):10417-22
PubMed ID: 8816815
The ZnuABC high-affinity zinc uptake system and its regulator Zur in Escherichia coli.
Patzer SI, Hantke K
Mol. Microbiol. 1998 Jun;28(6):1199-210
PubMed ID: 9680209
The transcriptional regulator Np20 is the zinc uptake regulator in Pseudomonas aeruginosa.
Ellison ML, Farrow JM, Farrow JM, Parrish W, Danell AS, Pesci EC
PLoS ONE 2013 ;8(9):e75389
PubMed ID: 24086521