Pseudomonas aeruginosa PAO1, PA5557 (atpH)

Cytoplasmic Membrane
Outer Membrane
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
Synonym: uncH
Synonym: papE
Replicon chromosome
Genomic location 6252159 - 6252695 (- strand)
Transposon Mutants 2 transposon mutants in PAO1


RefSeq NP_254244.1
GI 15600750
Affymetrix PA5557_atpH_at
DNASU PaCD00007315
Entrez 878509
GenBank AAG08942.1
INSDC AAG08942.1
NCBI Locus Tag PA5557
protein_id(GenBank) gb|AAG08942.1|AE004967_13|gnl|PseudoCAP|PA5557
UniParc UPI00000C6071
UniProtKB Acc Q9HT17
UniRef100 UniRef100_A6VF35
UniRef50 UniRef50_A6VF35
UniRef90 UniRef90_A6VF35


Feature Type CDS
Coding Frame 1
Product Name
ATP synthase delta chain
Product Name Confidence: Class 2
Evidence for Translation
Detected by two-dimensional gel electrophoresis and mass spectral analysis(PMID:21863142).
Detected using LC-MS/MS (19.26 kDa, PMID:21751344)
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.55
Kyte-Doolittle Hydrophobicity Value -0.142
Molecular Weight (kDa) 19.3
Isoelectric Point (pI) 5.85

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 1
Cytoplasmic Class 3
Outer Membrane Vesicle Class 1
Additional evidence for subcellular localization
Detetected in a periplasmic protein preparation by spheroplasting by osmotic shock.(PMID:19333994)

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 459 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG005088 (552 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA5557
Search term: atpH

Human Homologs

Ensembl 94, assembly GRCh38.p12
ATP synthase peripheral stalk subunit OSCP [Source:HGNC Symbol;Acc:HGNC:850]
E-value: 2.3e-08
Percent Identity: 27.6


The atp operon: nucleotide sequence of the promoter and the genes for the membrane proteins, and the delta subunit of Escherichia coli ATP-synthase.
Gay NJ, Walker JE
Nucleic Acids Res. 1981 Aug;9(16):3919-26
PubMed ID: 6272190
Solution structure of the N-terminal domain of the delta subunit of the E. coli ATPsynthase.
Wilkens S, Dunn SD, Chandler J, Dahlquist FW, Capaldi RA
Nat. Struct. Biol. 1997 Mar;4(3):198-201
PubMed ID: 9164460
Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient.
Rao J, Damron FH, Basler M, Digiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB
Front Microbiol 2011 ;2
PubMed ID: 21863142
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344