Pseudomonas putida BIRD-1, PPUBIRD1_3225

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in GBrowse

Gene Feature Overview

Strain Pseudomonas putida BIRD-1
GCF_000183645.1|latest
Locus Tag
PPUBIRD1_3225
Name
Replicon chromosome
Genomic location 3609619 - 3610707 (+ strand)

Cross-References

RefSeq YP_005931029.1
GI 386012752
EC Number 3.5.1.38
Entrez 12521394
NCBI Locus Tag PPUBIRD1_3225

Product

Feature Type CDS
Coding Frame 1
Product Name
Glutaminase-asparaginase
Synonyms
Evidence for Translation
Charge (pH 7) 1.21
Kyte-Doolittle Hydrophobicity Value -0.108
Molecular Weight (kDa) 38.6
Isoelectric Point (pI) 7.84

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3PGA BACTERIAL AMIDOHYDROLASE 07/19/94 STRUCTURAL CHARACTERIZATION OF PSEUDOMONAS 7A GLUTAMINASE-ASPARAGINASE PSEUDOMONAS SP. 7A 2.0 X-RAY DIFFRACTION 92.4
1DJO HYDROLASE/HYDROLASE INHIBITOR 12/03/99 Crystal structure of Pseudomonas 7A Glutaminase-asparaginase with the inhibitor donv covalently bound in the active site PSEUDOMONAS SP. 2.0 X-RAY DIFFRACTION 95.5
1DJP HYDROLASE 12/03/99 CRYSTAL STRUCTURE OF PSEUDOMONAS 7A GLUTAMINASE-ASPARAGINASE WITH THE INHIBITOR DON COVALENTLY BOUND IN THE ACTIVE SITE PSEUDOMONAS SP. 1.9 X-RAY DIFFRACTION 95.5
4PGA BACTERIAL AMIDOHYDROLASE 01/14/97 GLUTAMINASE-ASPARAGINASE FROM PSEUDOMONAS 7A PSEUDOMONAS SP. 7A 1.7 X-RAY DIFFRACTION 95.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
2-Amino-6-Oxo-Hexanoic Acid DB02571 DrugBank 5.1.4 Q88K39 Glutaminase-asparaginase 99.7 362 1.4e-195
Threonine-Aspartic Ester DB01817 DrugBank 5.1.4 P00805 L-asparaginase 2 45.4 359 2.6e-74
4-Carboxy-4-Aminobutanal DB04388 DrugBank 5.1.4 Q88K39 Glutaminase-asparaginase 99.7 362 1.4e-195

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 351 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001273 (467 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PPUBIRD1_3225

References

No references are associated with this feature.