Pseudomonas aeruginosa UCBPP-PA14, PA14_05520 (mexR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14
GCF_000014625.1|latest
Locus Tag
PA14_05520
Name
mexR
Replicon chromosome
Genomic location 486057 - 486500 (- strand)
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq YP_788598.1
GI 116054155
Entrez 4384292
INSDC ABJ15391.1
NCBI Locus Tag PA14_05520
UniParc UPI00000061D9
UniProtKB Acc Q02TY8
UniProtKB ID Q02TY8_PSEAB
UniRef100 UniRef100_W0YLI3
UniRef50 UniRef50_P52003
UniRef90 UniRef90_P52003

Product

Feature Type CDS
Coding Frame 1
Product Name
multidrug resistance operon repressor MexR
Synonyms
Evidence for Translation
Charge (pH 7) -4.65
Kyte-Doolittle Hydrophobicity Value -0.407
Molecular Weight (kDa) 17.0
Isoelectric Point (pI) 5.57

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
MexR MexR is the repressor of the MexRAB-OprM operon. Mutant forms of mexR result in up-regulation of efflux pump system MexAB-OprM. ARO:3000506 protein overexpression model Strict 292.4 99.32 3.0.2

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1LNW TRANSCRIPTION REPRESSOR 05/03/02 CRYSTAL STRUCTURE OF THE MEXR REPRESSOR OF THE MEXAB-OPRM MULTIDRUG EFFLUX OPERON OF PSEUDOMONAS AERUGINOSA PSEUDOMONAS AERUGINOSA 2.1 X-RAY DIFFRACTION 99.3
4ZZL TRANSCRIPTION 04/10/15 MexR R21W derepressor mutant causing multidrug resistance in P. aeruginosa by mexAB-oprM efflux pump expression PSEUDOMONAS AERUGINOSA 2.19 X-RAY DIFFRACTION 98.5
3MEX Transcription, Transcription Regulation 04/01/10 Crystal structure of MexR in oxidized state PSEUDOMONAS AERUGINOSA 2.1 X-RAY DIFFRACTION 98.6
3ECH Transcription, Transcription regulation 08/30/08 The MarR-family repressor MexR in complex with its antirepressor ArmR PSEUDOMONAS AERUGINOSA 1.802 X-RAY DIFFRACTION 97.9

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 244 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000415 (302 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_05520
Search term: mexR

References

No references are associated with this feature.