Pseudomonas aeruginosa UCBPP-PA14, PA14_05550 (oprM)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag
PA14_05550
Name
oprM
Replicon chromosome
Genomic location 491084 - 492541 (+ strand)
Transposon Mutants 2 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq YP_788601.1
GI 116054158
Entrez 4384295
INSDC ABJ15394.1
NCBI Locus Tag PA14_05550
UniParc UPI0000130D9F
UniProtKB Acc Q02TY5
UniProtKB ID Q02TY5_PSEAB
UniRef100 UniRef100_Q51487
UniRef50 UniRef50_Q51487
UniRef90 UniRef90_Q51487

Product

Feature Type CDS
Coding Frame 1
Product Name
major intrinsic multiple antibiotic resistance efflux outer membrane protein OprM precursor
Synonyms
Evidence for Translation
Charge (pH 7) -2.79
Kyte-Doolittle Hydrophobicity Value -0.215
Molecular Weight (kDa) 52.6
Isoelectric Point (pI) 5.32

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
OprM OprM is an outer membrane factor protein found in Pseudomonas aeruginosa and Burkholderia vietnamiensis. It is part of the MexAB-OprM, MexVW-OprM, MexXY-OprM and the AmrAB-OprM complex. ARO:3000379 protein homolog model Perfect 916.8 100.0 3.0.1

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1WP1 MEMBRANE PROTEIN 08/28/04 Crystal structure of the drug-discharge outer membrane protein, OprM PSEUDOMONAS AERUGINOSA 2.56 X-RAY DIFFRACTION 100.0
3D5K MEMBRANE PROTEIN 05/16/08 Crystal structure of the OprM channel in a non-symmetrical space group PSEUDOMONAS AERUGINOSA 2.4 X-RAY DIFFRACTION 100.0
4Y1K MEMBRANE PROTEIN 02/07/15 PALMITOYLATED OPRM OUTER MEMBRANE FACTOR PSEUDOMONAS AERUGINOSA 3.8 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 316 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000418 (551 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_05550
Search term: oprM

References

No references are associated with this feature.