Pseudomonas aeruginosa UCBPP-PA14, PA14_05620 (sahH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14
GCF_000014625.1|latest
Locus Tag
PA14_05620
Name
sahH
Replicon chromosome
Genomic location 497457 - 498866 (- strand)
Transposon Mutants 2 transposon mutants in UCBPP-PA14

Cross-References

RefSeq YP_788606.1
GI 116054163
EC Number 3.3.1.1
Entrez 4384300
INSDC ABJ15399.1
NCBI Locus Tag PA14_05620
UniParc UPI0000E448C7
UniProtKB Acc Q02TY0
UniProtKB ID SAHH_PSEAB
UniRef100 UniRef100_Q02TY0
UniRef50 UniRef50_Q4K4H7
UniRef90 UniRef90_A4XPF3

Product

Feature Type CDS
Coding Frame 1
Product Name
S-adenosyl-L-homocysteine hydrolase
Synonyms
Evidence for Translation
Charge (pH 7) -7.58
Kyte-Doolittle Hydrophobicity Value -0.185
Molecular Weight (kDa) 51.4
Isoelectric Point (pI) 5.82

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6F3N HYDROLASE 11/28/17 Crystal structure of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa cocrystallized with SAH in the presence of K+ and Zn2+ cations PSEUDOMONAS AERUGINOSA (STRAIN ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.85 X-RAY DIFFRACTION 99.8
6F3M HYDROLASE 11/28/17 Crystal structure of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa complexed with adenosine, K+ and Zn2+ cations PSEUDOMONAS AERUGINOSA (STRAIN ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.6 X-RAY DIFFRACTION 99.8
6F3O HYDROLASE 11/28/17 Crystal structure of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa complexed with adenine, K+ and Zn2+ cations PSEUDOMONAS AERUGINOSA (STRAIN ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.75 X-RAY DIFFRACTION 99.8
6F3P HYDROLASE 11/28/17 Crystal structure of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa in complex with 3'-deoxyadenosine and K+ cation PSEUDOMONAS AERUGINOSA (STRAIN ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.35 X-RAY DIFFRACTION 99.8
6F3Q HYDROLASE 11/28/17 Crystal structure of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa in complex with adenine and Rb+ cation PSEUDOMONAS AERUGINOSA (STRAIN ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.45 X-RAY DIFFRACTION 99.8

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 500 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000423 (554 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_05620
Search term: sahH

Human Homologs

Ensembl 97, assembly GRCh38.p12
adenosylhomocysteinase [Source:HGNC Symbol;Acc:HGNC:343]
E-value: 1.1e-134
Percent Identity: 56.2

References

No references are associated with this feature.