Pseudomonas aeruginosa UCBPP-PA14, PA14_59960 (dsbA2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14
GCF_000014625.1|latest
Locus Tag
PA14_59960
Name
dsbA2
Synonym: PadsbA2
Synonym: RL020
Replicon chromosome
Genomic location 5340274 - 5340933 (+ strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq YP_792984.1
GI 116052668
Entrez 4382757
INSDC ABJ13904.1
NCBI Locus Tag PA14_59960
UniParc UPI00001B252C
UniProtKB Acc Q02GF2
UniProtKB ID Q02GF2_PSEAB
UniRef100 UniRef100_Q02GF2
UniRef50 UniRef50_G8CNY3
UniRef90 UniRef90_Z2DHT0

Product

Feature Type CDS
Coding Frame 1
Product Name
DsbA2
Product Name Confidence: Class 1
Synonyms protein-disulfide isomerase
Evidence for Translation
Charge (pH 7) 0.08
Kyte-Doolittle Hydrophobicity Value -0.069
Molecular Weight (kDa) 23.8
Isoelectric Point (pI) 7.03

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4N30 OXIDOREDUCTASE 10/06/13 Crystal structure of Pseudomonas aeruginosa DsbA2 PSEUDOMONAS AERUGINOSA 1.3 X-RAY DIFFRACTION 100.0

Virulence Evidence

Source 1
Database PseudoCAP
Category Not available / Not known
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Arabidopsis thaliana
Notes
Infection model Arabidopsis leaf infiltration model
Reference 14983043
Source 2
Database PseudoCAP
Category Not available / Not known
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mus musculus
Notes
Infection model Mouse thermal injury model.
Reference 14983043

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 113 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000946 (300 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_59960
Search term: dsbA2
Search term: DsbA2

References

Dissecting the machinery that introduces disulfide bonds in Pseudomonas aeruginosa.
Arts IS, Ball G, Leverrier P, Garvis S, Nicolaes V, Vertommen D, Ize B, Tamu Dufe V, Messens J, Voulhoux R, Collet JF
MBio 2013 Dec;4(6):e00912-13
PubMed ID: 24327342
The broad host range pathogen Pseudomonas aeruginosa strain PA14 carries two pathogenicity islands harboring plant and animal virulence genes.
He J, Baldini RL, Déziel E, Saucier M, Zhang Q, Liberati NT, Lee D, Urbach J, Goodman HM, Rahme LG
Proc. Natl. Acad. Sci. U.S.A. 2004 Feb;101(8):2530-5
PubMed ID: 14983043