Pseudomonas aeruginosa UCBPP-PA14, PA14_71990 (gmd)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag
PA14_71990
Name
gmd
Replicon chromosome
Genomic location 6416029 - 6417000 (- strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 5 transposon mutants in orthologs

Cross-References

RefSeq YP_793930.1
GI 116053603
Entrez 4384948
INSDC ABJ14839.1
NCBI Locus Tag PA14_71990
UniParc UPI000012B8A1
UniProtKB Acc Q02DQ6
UniProtKB ID Q02DQ6_PSEAB
UniRef100 UniRef100_Q51366
UniRef50 UniRef50_Q51366
UniRef90 UniRef90_Q51366

Product

Feature Type CDS
Coding Frame 1
Product Name
GDP-mannose 4,6-dehydratase
Synonyms
Evidence for Translation
Charge (pH 7) -1.61
Kyte-Doolittle Hydrophobicity Value -0.291
Molecular Weight (kDa) 36.4
Isoelectric Point (pI) 6.53

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1RPN LYASE 12/03/03 Crystal Structure of GDP-D-mannose 4,6-dehydratase in complexes with GDP and NADPH PSEUDOMONAS AERUGINOSA 2.15 X-RAY DIFFRACTION 100.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
Guanosine-5'-Diphosphate DB04315 DrugBank 5.1.1 Q51366 GDP-mannose 4,6-dehydratase 100.0 323 9.6e-187

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 611 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004999 (389 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_71990
Search term: gmd

Human Homologs

Ensembl 94, assembly GRCh38.p12
GDP-mannose 4,6-dehydratase [Source:HGNC Symbol;Acc:HGNC:4369]
E-value: 2.6e-87
Percent Identity: 48.2

References

No references are associated with this feature.