Strain |
Pseudomonas aeruginosa PA7
GCF_000017205.1|latest |
Locus Tag |
PSPA7_0526
|
Name |
mexB
|
Replicon | chromosome |
Genomic location | 539564 - 542704 (+ strand) |
RefSeq | YP_001345921.1 |
GI | 152989597 |
Entrez | 5356306 |
INSDC | ABR86780.1 |
NCBI Locus Tag | PSPA7_0526 |
UniParc | UPI00015770E2 |
UniProtKB Acc | A6UYN6 |
UniProtKB ID | A6UYN6_PSEA7 |
UniRef100 | UniRef100_A6UYN6 |
UniRef50 | UniRef50_P52002 |
UniRef90 | UniRef90_P52002 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
RND multidrug efflux transporter MexB
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | -9.89 |
Kyte-Doolittle Hydrophobicity Value | 0.269 |
Molecular Weight (kDa) | 112.8 |
Isoelectric Point (pI) | 5.40 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
MexB | MexB is the inner membrane multidrug exporter of the efflux complex MexAB-OprM. [PMID:19361527, PMID:21178960, PMID:14973037, PMID:20583998] | ARO:3000378 | protein homolog model | Strict | 1974.5 | 99.24 | 3.2.5 |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
6IOL | MEMBRANE PROTEIN | 10/30/18 | Cryo-EM structure of multidrug efflux pump MexAB-OprM (60 degree state) | Pseudomonas aeruginosa; Pseudomonas aeruginosa PAO1 | 3.76 | ELECTRON MICROSCOPY | 99.3 |
3W9I | MEMBRANE PROTEIN | 04/04/13 | Structural basis for the inhibition of bacterial multidrug exporters | Pseudomonas aeruginosa | 2.71 | X-RAY DIFFRACTION | 99.3 |
2V50 | MEMBRANE PROTEIN | 10/01/08 | The Missing Part of the Bacterial MexAB-OprM System: Structural determination of the Multidrug Exporter MexB | PSEUDOMONAS AERUGINOSA PA01 | 3 | X-RAY DIFFRACTION | 99.5 |
6IOK | MEMBRANE PROTEIN | 10/30/18 | Cryo-EM structure of multidrug efflux pump MexAB-OprM (0 degree state) | Pseudomonas aeruginosa PAO1 | 3.64 | ELECTRON MICROSCOPY | 99.3 |
6IIA | MEMBRANE PROTEIN | 10/04/18 | MexB in complex with LMNG | Pseudomonas aeruginosa PAO1 | 2.91 | X-RAY DIFFRACTION | 99.5 |
3W9J | MEMBRANE PROTEIN | 04/04/13 | Structural basis for the inhibition of bacterial multidrug exporters | Pseudomonas aeruginosa | 3.15 | X-RAY DIFFRACTION | 99.5 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 488 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG000417 (2093 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PSPA7_0526
Search term: mexB
Search term: RND multidrug efflux transporter MexB
|