Pseudomonas aeruginosa PA7, PSPA7_0530 (metF)

Gene Feature Overview

Strain	Pseudomonas aeruginosa PA7 GCF_000017205.1|latest
Locus Tag	PSPA7_0530
Name	metF
Replicon	chromosome
Genomic location	547555 - 548403 (- strand)

Cross-References

RefSeq	YP_001345925.1
GI	152988219
EC Number	1.5.1.20
Entrez	5358452
INSDC	ABR85402.1
NCBI Locus Tag	PSPA7_0530
UniParc	UPI0000D72D8A
UniProtKB Acc	A6UYP0
UniProtKB ID	A6UYP0_PSEA7
UniRef100	UniRef100_A6UYP0
UniRef50	UniRef50_G2DES0
UniRef90	UniRef90_A6UYP0

Product

Feature Type	CDS
Coding Frame	1
Product Name	5,10-methylenetetrahydrofolate reductase
Synonyms
Evidence for Translation
Charge (pH 7)	-0.44
Kyte-Doolittle Hydrophobicity Value	-0.237
Molecular Weight (kDa)	31.3
Isoelectric Point (pI)	6.88

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 396 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG000421 (535 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PSPA7_0530 Search term: metF Search term: 5,10-methylenetetrahydrofolate reductase

Human Homologs

Ensembl 110, assembly GRCh38.p14	ENSP00000493262 methylenetetrahydrofolate reductase [Source:HGNC Symbol;Acc:HGNC:7436] E-value: 2.0e-42 Percent Identity: 34.9
Ensembl 110, assembly GRCh38.p14	ENSP00000365767 methylenetetrahydrofolate reductase [Source:HGNC Symbol;Acc:HGNC:7436] E-value: 2.0e-42 Percent Identity: 34.9
Ensembl 110, assembly GRCh38.p14	ENSP00000398908 methylenetetrahydrofolate reductase [Source:HGNC Symbol;Acc:HGNC:7436] E-value: 2.0e-42 Percent Identity: 34.9
Ensembl 110, assembly GRCh38.p14	ENSP00000365777 methylenetetrahydrofolate reductase [Source:HGNC Symbol;Acc:HGNC:7436] E-value: 2.0e-42 Percent Identity: 34.9
Ensembl 110, assembly GRCh38.p14	ENSP00000493098 methylenetetrahydrofolate reductase [Source:HGNC Symbol;Acc:HGNC:7436] E-value: 2.0e-42 Percent Identity: 34.9
Ensembl 110, assembly GRCh38.p14	ENSP00000365775 methylenetetrahydrofolate reductase [Source:HGNC Symbol;Acc:HGNC:7436] E-value: 2.0e-42 Percent Identity: 34.9
Ensembl 110, assembly GRCh38.p14	ENSP00000365770 methylenetetrahydrofolate reductase [Source:HGNC Symbol;Acc:HGNC:7436] E-value: 2.0e-42 Percent Identity: 34.9

References