Pseudomonas aeruginosa M18, PAM18_0046 (exoT)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa M18
GCF_000226155.1|latest
Locus Tag
PAM18_0046
Name
exoT
Replicon chromosome
Genomic location 57929 - 59302 (+ strand)

Cross-References

RefSeq YP_005972639.1
GI 386056117
Entrez 12564064
NCBI Locus Tag PAM18_0046

Product

Feature Type CDS
Coding Frame 1
Product Name
exoenzyme T
Synonyms
Evidence for Translation
Charge (pH 7) -9.33
Kyte-Doolittle Hydrophobicity Value -0.286
Molecular Weight (kDa) 48.4
Isoelectric Point (pI) 5.49

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4JMF TOXIN/CHAPERONE 03/14/13 Crystal structure of ExoT (residues 28 -77)- SpcS complex from Pseudomonas aeruginosa at 2.1 angstrom Pseudomonas aeruginosa 2.099 X-RAY DIFFRACTION 100.0
6GNN TOXIN 05/31/18 Exoenzyme T from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, tetrameric crystal form bound to STO1101 Homo sapiens; Pseudomonas aeruginosa PAO1 3.79 X-RAY DIFFRACTION 98.2
6JNP TOXIN 03/17/19 Structure of ExoT-SpcS Complex from Pseudomonas aeruginosa in 2.2 Angstrom Pseudomonas aeruginosa 2.261 X-RAY DIFFRACTION 98.2

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 8 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000044 (294 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PAM18_0046
Search term: exoT
Search term: exoenzyme T

Human Homologs

References

No references are associated with this feature.