Strain |
Pseudomonas aeruginosa M18
GCF_000226155.1|latest |
Locus Tag |
PAM18_3883
|
Name |
toxA
|
Replicon | chromosome |
Genomic location | 4315653 - 4317569 (+ strand) |
RefSeq | YP_005976466.1 |
GI | 386059944 |
Entrez | 12567937 |
NCBI Locus Tag | PAM18_3883 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
exotoxin A
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | -16.15 |
Kyte-Doolittle Hydrophobicity Value | -0.267 |
Molecular Weight (kDa) | 69.3 |
Isoelectric Point (pI) | 5.29 |
Individual Mappings | |
Additional evidence for subcellular localization |
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
1ZM3 | BIOSYNTHETIC PROTEIN/TRANSFERASE | 05/10/05 | Structure of the apo eEF2-ETA complex | Pseudomonas aeruginosa; Saccharomyces cerevisiae | 3.07 | X-RAY DIFFRACTION | 99.5 |
1ZM4 | BIOSYNTHETIC PROTEIN/TRANSFERASE | 05/10/05 | Structure of the eEF2-ETA-bTAD complex | Pseudomonas aeruginosa; Saccharomyces cerevisiae | 2.9 | X-RAY DIFFRACTION | 99.5 |
6EDG | TRANSFERASE | 08/09/18 | Pseudomonas exotoxin A domain III T18H477L | Pseudomonas aeruginosa | 1.47 | X-RAY DIFFRACTION | 97.2 |
1DMA | ADP-RIBOSYLATION | 04/28/95 | DOMAIN III OF PSEUDOMONAS AERUGINOSA EXOTOXIN COMPLEXED WITH NICOTINAMIDE AND AMP | Pseudomonas aeruginosa | 2.5 | X-RAY DIFFRACTION | 99.5 |
1IKQ | TRANSFERASE | 05/04/01 | Pseudomonas Aeruginosa Exotoxin A, wild type | Pseudomonas aeruginosa | 1.62 | X-RAY DIFFRACTION | 99.5 |
1XK9 | TRANSFERASE | 09/28/04 | Pseudomanas exotoxin A in complex with the PJ34 inhibitor | Pseudomonas aeruginosa | 2.1 | X-RAY DIFFRACTION | 99.5 |
1AER | ADP-RIBOSYLATION | 12/11/95 | DOMAIN III OF PSEUDOMONAS AERUGINOSA EXOTOXIN COMPLEXED WITH BETA-TAD | Pseudomonas aeruginosa | 2.3 | X-RAY DIFFRACTION | 99.5 |
2ZIT | BIOSYNTHETIC PROTEIN/TRANSFERASE | 02/24/08 | Structure of the eEF2-ExoA-NAD+ complex | Pseudomonas aeruginosa; Saccharomyces cerevisiae | 3 | X-RAY DIFFRACTION | 99.5 |
1IKP | TRANSFERASE | 05/04/01 | Pseudomonas Aeruginosa Exotoxin A, P201Q, W281A mutant | Pseudomonas aeruginosa | 1.45 | X-RAY DIFFRACTION | 99.2 |
1ZM9 | BIOSYNTHETIC PROTEIN/TRANSFERASE | 05/10/05 | Structure of eEF2-ETA in complex with PJ34 | Pseudomonas aeruginosa; Saccharomyces cerevisiae | 2.8 | X-RAY DIFFRACTION | 99.5 |
1ZM2 | BIOSYNTHETIC PROTEIN/TRANSFERASE | 05/10/05 | Structure of ADP-ribosylated eEF2 in complex with catalytic fragment of ETA | Pseudomonas aeruginosa; Saccharomyces cerevisiae | 3.07 | X-RAY DIFFRACTION | 99.5 |
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE | DB08348 | DrugBank | 5.1.4 | Q5EK40 | Cholix toxin | 32.6 | 693 | 6.8e-84 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in one genus
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG001108 (295 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PAM18_3883
Search term: toxA
Search term: exotoxin A
|