Pseudomonas aeruginosa M18, PAM18_4048 (pqsE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa M18
GCF_000226155.1|latest
Locus Tag
PAM18_4048
Name
pqsE
Replicon chromosome
Genomic location 4483257 - 4484162 (- strand)

Cross-References

RefSeq YP_005976631.1
GI 386060109
Entrez 12568103
NCBI Locus Tag PAM18_4048

Product

Feature Type CDS
Coding Frame 1
Product Name
Quinolone signal response protein
Synonyms
Evidence for Translation
Charge (pH 7) -10.61
Kyte-Doolittle Hydrophobicity Value -0.178
Molecular Weight (kDa) 34.3
Isoelectric Point (pI) 5.25

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
8DQ0 TRANSCRIPTION 07/18/22 Quorum-sensing receptor RhlR bound to PqsE Pseudomonas aeruginosa 3.74 ELECTRON MICROSCOPY 100.0
7R3F HYDROLASE 02/07/22 Monomeric PqsE mutant E187R Pseudomonas aeruginosa PAO1 1.65 X-RAY DIFFRACTION 99.7
7R3J TRANSCRIPTION 02/07/22 Nativ complex of PqsE and RhlR with the synthetic antagonist mBTL Pseudomonas aeruginosa PAO1 3.06 X-RAY DIFFRACTION 100.0
5HIQ METAL BINDING PROTEIN 01/12/16 Crystal Structure of PQS Response Protein PqsE in Complex with 2-(1H-pyrrol-1-yl)benzoic acid Pseudomonas aeruginosa PAO1 2.1 X-RAY DIFFRACTION 100.0
2VW8 SIGNALING PROTEIN 06/17/08 Crystal Structure of Quinolone signal response protein pqsE from Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA PAO1 1.45 X-RAY DIFFRACTION 100.0
5HIP METAL BINDING PROTEIN 01/12/16 Crystal Structure of PQS Response Protein PqsE in Complex with 2-(pyridin-3-yl)benzoic acid Pseudomonas aeruginosa PAO1 1.992 X-RAY DIFFRACTION 100.0
2Q0I METAL BINDING PROTEIN 05/22/07 Structure of Pseudomonas Quinolone Signal Response Protein PqsE Pseudomonas aeruginosa 1.57 X-RAY DIFFRACTION 100.0
7TZ9 HYDROLASE 02/15/22 Structure of PQS Response Protein PqsE(E182W) Variant Pseudomonas aeruginosa 2.01 X-RAY DIFFRACTION 99.7
8DQ1 TRANSCRIPTION/DNA 07/18/22 Quorum-sensing receptor RhlR bound to PqsE Pseudomonas aeruginosa; SYNTHETIC CONSTRUCT 4.1 ELECTRON MICROSCOPY 100.0
7KGX HYDROLASE/Inhibitor 10/19/20 Structure of PQS Response Protein PqsE in Complex with 4-(3-(2-methyl-2-morpholinobutyl)ureido)-N-(thiazol-2-yl)benzamide Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2 X-RAY DIFFRACTION 100.0
7U6G HYDROLASE 03/04/22 Structure of PQS Response Protein PqsE(E182W,E280A) Variant Pseudomonas aeruginosa 2.45 X-RAY DIFFRACTION 99.3
3DH8 METAL BINDING PROTEIN 06/17/08 Structure of Pseudomonas Quinolone Signal Response Protein PqsE Pseudomonas aeruginosa 1.8 X-RAY DIFFRACTION 99.7
5HIS METAL BINDING PROTEIN 01/12/16 Crystal Structure of PQS Response Protein PqsE in Complex with 3-methylthiophene-2-carboxylic acid Pseudomonas aeruginosa PAO1 1.77 X-RAY DIFFRACTION 100.0
8B4A SIGNALING PROTEIN 09/20/22 Nativ complex of PqsE and RhlR with autoinducer C4-HSL Pseudomonas aeruginosa PAO1 3.06 X-RAY DIFFRACTION 100.0
2Q0J METAL BINDING PROTEIN 05/22/07 Structure of Pseudomonas Quinolone Signal Response Protein PqsE Pseudomonas aeruginosa 2.1 X-RAY DIFFRACTION 100.0
7KGW HYDROLASE/Inhibitor 10/19/20 Structure of PQS Response Protein PqsE in Complex N-(3-(1H-pyrazol-5-yl)phenyl)-1H-indazole-7-carboxamide Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.99 X-RAY DIFFRACTION 100.0
7TZA HYDROLASE/INHIBITOR 02/15/22 Structure of PQS Response Protein PqsE in complex with N-(4-(3-neopentylureido)phenyl)-1H-indazole-7-carboxamide Pseudomonas aeruginosa 2.1 X-RAY DIFFRACTION 100.0
7R3E TRANSCRIPTION 02/07/22 Fusion construct of PqsE and RhlR in complex with the synthetic antagonist mBTL Pseudomonas aeruginosa PAO1 3.46 X-RAY DIFFRACTION 100.0
5HIO METAL BINDING PROTEIN 01/12/16 Crystal Structure of PQS Response Protein PqsE in Complex with 2-aminobenzoylacetate Pseudomonas aeruginosa PAO1 1.9 X-RAY DIFFRACTION 100.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
bis(4-nitrophenyl) hydrogen phosphate DB07418 DrugBank 5.1.4 P20581 Uncharacterized protein PA1000 100.0 301 3.7e-178

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 100 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000963 (297 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PAM18_4048
Search term: pqsE

Human Homologs

References

No references are associated with this feature.