Pseudomonas aeruginosa RP73, M062_06260

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa RP73
GCF_000414035.1|latest
Locus Tag
M062_06260
Name
Replicon chromosome
Genomic location 1302258 - 1304174 (- strand)

Cross-References

RefSeq YP_008131699.1
GI 514408658
Entrez 15958995
NCBI Locus Tag M062_06260

Product

Feature Type CDS
Coding Frame 1
Product Name
exotoxin A
Synonyms
Evidence for Translation
Charge (pH 7) -16.12
Kyte-Doolittle Hydrophobicity Value -0.260
Molecular Weight (kDa) 69.3
Isoelectric Point (pI) 5.29

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1IKQ TRANSFERASE 05/04/01 Pseudomonas Aeruginosa Exotoxin A, wild type Pseudomonas aeruginosa 1.62 X-RAY DIFFRACTION 99.3
6EDG TRANSFERASE 08/09/18 Pseudomonas exotoxin A domain III T18H477L Pseudomonas aeruginosa 1.47 X-RAY DIFFRACTION 96.2
1IKP TRANSFERASE 05/04/01 Pseudomonas Aeruginosa Exotoxin A, P201Q, W281A mutant Pseudomonas aeruginosa 1.45 X-RAY DIFFRACTION 99.0
1AER ADP-RIBOSYLATION 12/11/95 DOMAIN III OF PSEUDOMONAS AERUGINOSA EXOTOXIN COMPLEXED WITH BETA-TAD Pseudomonas aeruginosa 2.3 X-RAY DIFFRACTION 98.6
1ZM9 BIOSYNTHETIC PROTEIN/TRANSFERASE 05/10/05 Structure of eEF2-ETA in complex with PJ34 Pseudomonas aeruginosa; Saccharomyces cerevisiae 2.8 X-RAY DIFFRACTION 98.6
2ZIT BIOSYNTHETIC PROTEIN/TRANSFERASE 02/24/08 Structure of the eEF2-ExoA-NAD+ complex Pseudomonas aeruginosa; Saccharomyces cerevisiae 3 X-RAY DIFFRACTION 98.5
1ZM4 BIOSYNTHETIC PROTEIN/TRANSFERASE 05/10/05 Structure of the eEF2-ETA-bTAD complex Pseudomonas aeruginosa; Saccharomyces cerevisiae 2.9 X-RAY DIFFRACTION 98.6
1DMA ADP-RIBOSYLATION 04/28/95 DOMAIN III OF PSEUDOMONAS AERUGINOSA EXOTOXIN COMPLEXED WITH NICOTINAMIDE AND AMP Pseudomonas aeruginosa 2.5 X-RAY DIFFRACTION 98.6
1XK9 TRANSFERASE 09/28/04 Pseudomanas exotoxin A in complex with the PJ34 inhibitor Pseudomonas aeruginosa 2.1 X-RAY DIFFRACTION 98.6
1ZM3 BIOSYNTHETIC PROTEIN/TRANSFERASE 05/10/05 Structure of the apo eEF2-ETA complex Pseudomonas aeruginosa; Saccharomyces cerevisiae 3.07 X-RAY DIFFRACTION 98.6
1ZM2 BIOSYNTHETIC PROTEIN/TRANSFERASE 05/10/05 Structure of ADP-ribosylated eEF2 in complex with catalytic fragment of ETA Pseudomonas aeruginosa; Saccharomyces cerevisiae 3.07 X-RAY DIFFRACTION 98.6

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in one genus

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001108 (295 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: M062_06260
Search term: exotoxin A

Human Homologs

References

No references are associated with this feature.