Pseudomonas aeruginosa 2192, PA2G_00134

Gene Feature Overview

Strain	Pseudomonas aeruginosa 2192 GCF_000152545.1|latest
Locus Tag	PA2G_00134
Name
Replicon	chromosome
Genomic location	133127 - 135043 (- strand)

Cross-References

RefSeq	ZP_04932842.1
GI	254239520
NCBI Locus Tag	PA2G_00134
UniProtKB Acc	A3L9J5
UniProtKB ID	A3L9J5_PSEAE

Product

Feature Type	CDS
Coding Frame	1
Product Name	exotoxin A
Synonyms
Evidence for Translation
Charge (pH 7)	-16.12
Kyte-Doolittle Hydrophobicity Value	-0.263
Molecular Weight (kDa)	69.4
Isoelectric Point (pI)	5.30

Subcellular localization

Individual Mappings	Localization Confidence PMID Extracellular Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
1IKP	TRANSFERASE	05/04/01	Pseudomonas Aeruginosa Exotoxin A, P201Q, W281A mutant	Pseudomonas aeruginosa	1.45	X-RAY DIFFRACTION	99.0
1ZM3	BIOSYNTHETIC PROTEIN/TRANSFERASE	05/10/05	Structure of the apo eEF2-ETA complex	Pseudomonas aeruginosa; Saccharomyces cerevisiae	3.07	X-RAY DIFFRACTION	99.0
1IKQ	TRANSFERASE	05/04/01	Pseudomonas Aeruginosa Exotoxin A, wild type	Pseudomonas aeruginosa	1.62	X-RAY DIFFRACTION	99.3
1ZM2	BIOSYNTHETIC PROTEIN/TRANSFERASE	05/10/05	Structure of ADP-ribosylated eEF2 in complex with catalytic fragment of ETA	Pseudomonas aeruginosa; Saccharomyces cerevisiae	3.07	X-RAY DIFFRACTION	99.0
1ZM9	BIOSYNTHETIC PROTEIN/TRANSFERASE	05/10/05	Structure of eEF2-ETA in complex with PJ34	Pseudomonas aeruginosa; Saccharomyces cerevisiae	2.8	X-RAY DIFFRACTION	99.0
1ZM4	BIOSYNTHETIC PROTEIN/TRANSFERASE	05/10/05	Structure of the eEF2-ETA-bTAD complex	Pseudomonas aeruginosa; Saccharomyces cerevisiae	2.9	X-RAY DIFFRACTION	99.0
1XK9	TRANSFERASE	09/28/04	Pseudomanas exotoxin A in complex with the PJ34 inhibitor	Pseudomonas aeruginosa	2.1	X-RAY DIFFRACTION	99.1
1AER	ADP-RIBOSYLATION	12/11/95	DOMAIN III OF PSEUDOMONAS AERUGINOSA EXOTOXIN COMPLEXED WITH BETA-TAD	Pseudomonas aeruginosa	2.3	X-RAY DIFFRACTION	99.0
2ZIT	BIOSYNTHETIC PROTEIN/TRANSFERASE	02/24/08	Structure of the eEF2-ExoA-NAD+ complex	Pseudomonas aeruginosa; Saccharomyces cerevisiae	3	X-RAY DIFFRACTION	99.0
6EDG	TRANSFERASE	08/09/18	Pseudomonas exotoxin A domain III T18H477L	Pseudomonas aeruginosa	1.47	X-RAY DIFFRACTION	96.7
1DMA	ADP-RIBOSYLATION	04/28/95	DOMAIN III OF PSEUDOMONAS AERUGINOSA EXOTOXIN COMPLEXED WITH NICOTINAMIDE AND AMP	Pseudomonas aeruginosa	2.5	X-RAY DIFFRACTION	99.1

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG001108 (295 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA2G_00134 Search term: exotoxin A

Human Homologs

References