Pseudomonas protegens Pf-5, PFL_1319 (pcaF)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas protegens Pf-5
GCF_000012265.1|latest
Locus Tag
PFL_1319
Name
pcaF
Replicon chromosome
Genomic location 1493177 - 1494379 (+ strand)

Cross-References

RefSeq YP_258448.1
GI 70728699
EC Number 2.3.1.-
Entrez 3478138
INSDC AAY90604.1
NCBI Locus Tag PFL_1319
UniParc UPI000054D06A
UniProtKB Acc Q4KH35
UniProtKB ID Q4KH35_PSEF5
UniRef100 UniRef100_Q4KH35
UniRef50 UniRef50_P0C7L2
UniRef90 UniRef90_G8PXF7

Product

Feature Type CDS
Coding Frame 1
Product Name
beta-ketoadipyl CoA thiolase
Synonyms
Evidence for Translation
Charge (pH 7) -2.90
Kyte-Doolittle Hydrophobicity Value 0.099
Molecular Weight (kDa) 41.6
Isoelectric Point (pI) 6.07

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6PCC TRANSFERASE 06/17/19 Crystal structure of beta-ketoadipyl-CoA thiolase mutant (H356A) in complex hexanoyl coenzyme A Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) 1.96 X-RAY DIFFRACTION 90.0
6PCB TRANSFERASE 06/17/19 Crystal structure of beta-ketoadipyl-CoA thiolase mutant (H356A) in complex with COA Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) 1.61 X-RAY DIFFRACTION 90.0
6PCA TRANSFERASE 06/17/19 Crystal structure of beta-ketoadipyl-CoA thiolase Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440) 1.81 X-RAY DIFFRACTION 90.2

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 485 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000227 (529 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PFL_1319
Search term: pcaF

Human Homologs

Ensembl 110, assembly GRCh38.p14
acetyl-CoA acyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:83]
E-value: 2.0e-80
Percent Identity: 43.8

References

No references are associated with this feature.