Pseudomonas aeruginosa LESB58, PALES_29171 (pvdQ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa LESB58
GCF_000026645.1|latest
Locus Tag
PALES_29171
Name
pvdQ
Replicon chromosome
Genomic location 3206318 - 3208606 (+ strand)

Cross-References

RefSeq YP_002440506
GI 218891639
Entrez 7180815

Product

Feature Type CDS
Coding Frame 1
Product Name
PvdQ
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -0.50
Kyte-Doolittle Hydrophobicity Value -0.335
Molecular Weight (kDa) 84.0
Isoelectric Point (pI) 6.91

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3L91 HYDROLASE 01/04/10 Structure of Pseudomonas aerugionsa PvdQ bound to octanoate Pseudomonas aeruginosa 1.66 X-RAY DIFFRACTION 99.6
4BTH HYDROLASE 06/18/13 The LeuA146Trp,PheB24Tyr Double Mutant of the Quorum Quenching N-acyl Homoserine Lactone Acylase PvdQ Has an Altered Substrate Specificity Towards Small Acyl Chains PSEUDOMONAS AERUGINOSA 1.9 X-RAY DIFFRACTION 99.5
2WYC HYDROLASE 11/16/09 The quorum quenching N-acyl homoserine lactone acylase PvdQ in complex with 3-oxo-lauric acid PSEUDOMONAS AERUGINOSA 1.9 X-RAY DIFFRACTION 99.6
4K2G HYDROLASE/HYDROLASE INHIBITOR 04/09/13 Structure of Pseudomonas aeruginosa PvdQ bound to BRD-A33442372 Pseudomonas aeruginosa 2.3 X-RAY DIFFRACTION 99.6
4K2F HYDROLASE/HYDROLASE INHIBITOR 04/09/13 Structure of Pseudomonas aeruginosa PvdQ bound to BRD-A08522488 Pseudomonas aeruginosa 1.99 X-RAY DIFFRACTION 99.6
3SRB HYDROLASE/HYDROLASE INHIBITOR 07/07/11 Structure of Pseudomonas aeruginosa PvdQ bound to SMER28 Pseudomonas aeruginosa 1.8 X-RAY DIFFRACTION 99.6
3L94 HYDROLASE 01/04/10 Structure of PvdQ covalently acylated with myristate Pseudomonas aeruginosa 1.95 X-RAY DIFFRACTION 99.6
4WKS HYDROLASE/HYDROLASE INHIBITOR 10/03/14 n-Alkylboronic Acid Inhibitors Reveal Determinants of Ligand Specificity in the Quorum-Quenching and Siderophore Biosynthetic Enzyme PvdQ Pseudomonas aeruginosa 1.629 X-RAY DIFFRACTION 99.6
4M1J HYDROLASE 08/02/13 Crystal structure of Pseudomonas aeruginosa PvdQ in complex with a transition state analogue Pseudomonas aeruginosa 1.8 X-RAY DIFFRACTION 99.6
5UBL HYDROLASE 12/20/16 A circularly permuted version of PvdQ (cpPvdQ) Pseudomonas aeruginosa 1.8 X-RAY DIFFRACTION 99.6
2WYD HYDROLASE 11/16/09 The quorum quenching N-acyl homoserine lactone acylase PvdQ in complex with dodecanoic acid PSEUDOMONAS AERUGINOSA 1.901 X-RAY DIFFRACTION 99.6
4WKT HYDROLASE/HYDROLASE Inhibitor 10/03/14 n-Alkylboronic Acid Inhibitors Reveal Determinants of Ligand Specificity in the Quorum-Quenching and Siderophore Biosynthetic Enzyme PvdQ Pseudomonas aeruginosa 1.782 X-RAY DIFFRACTION 99.6
4WKV HYDROLASE/HYDROLASE Inhibitor 10/03/14 n-Alkylboronic Acid Inhibitors Reveal Determinants of Ligand Specificity in the Quorum-Quenching and Siderophore Biosynthetic Enzyme PvdQ Pseudomonas aeruginosa 2.1434 X-RAY DIFFRACTION 99.6
2WYB HYDROLASE 11/16/09 The quorum quenching N-acyl homoserine lactone acylase PvdQ with a covalently bound dodecanoic acid PSEUDOMONAS AERUGINOSA 2.1 X-RAY DIFFRACTION 99.6
5UBK HYDROLASE 12/20/16 Inactive S1A/N269D-cpPvdQ mutant in complex with the pyoverdine precursor PVDIq reveals a specific binding pocket for the D-Tyr of this substrate Pseudomonas aeruginosa 2.55 X-RAY DIFFRACTION 99.3
3SRC HYDROLASE/HYDROLASE INHIBITOR 07/07/11 Structure of Pseudomonas aeruginosa PvdQ bound to NS2028 Pseudomonas aeruginosa 2 X-RAY DIFFRACTION 99.6
4WKU HYDROLASE/HYDROLASE Inhibitor 10/03/14 n-Alkylboronic Acid Inhibitors Reveal Determinants of Ligand Specificity in the Quorum-Quenching and Siderophore Biosynthetic Enzyme PvdQ Pseudomonas aeruginosa 2 X-RAY DIFFRACTION 99.6
3SRA HYDROLASE 07/07/11 Structure of Pseudomonas aerugionsa PvdQ covalently acylated with myristic acid from PVDIq Pseudomonas aeruginosa PAO1 2.3 X-RAY DIFFRACTION 99.6
2WYE HYDROLASE 11/16/09 The quorum quenching N-acyl homoserine lactone acylase PvdQ is an Ntn- Hydrolase with an unusual substrate-binding pocket PSEUDOMONAS AERUGINOSA 1.8 X-RAY DIFFRACTION 99.6

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 183 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003142 (466 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PALES_29171
Search term: pvdQ
Search term: PvdQ

Human Homologs

References

No references are associated with this feature.