Pseudomonas aeruginosa 2192, PA2G_04342

Gene Feature Overview

Strain	Pseudomonas aeruginosa 2192 GCF_000152545.1|latest
Locus Tag	PA2G_04342
Name
Replicon	chromosome
Genomic location	4844692 - 4847832 (+ strand)

Cross-References

RefSeq	ZP_04936846.1
GI	254243524
NCBI Locus Tag	PA2G_04342
UniProtKB Acc	A3LHN4
UniProtKB ID	A3LHN4_PSEAE

Product

Feature Type	CDS
Coding Frame	1
Product Name	multidrug transporter
Synonyms
Evidence for Translation
Charge (pH 7)	-10.65
Kyte-Doolittle Hydrophobicity Value	0.280
Molecular Weight (kDa)	112.8
Isoelectric Point (pI)	5.39

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Membrane Class 3 20472543
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name	Definition	Accession	Model Type (?)	SNP	Cutoff	Bit Score	Percent Identity	CARD Version
MexB	MexB is the inner membrane multidrug exporter of the efflux complex MexAB-OprM. [PMID:19361527, PMID:21178960, PMID:14973037, PMID:20583998]	ARO:3000378	protein homolog model		Strict	1969.1	99.33	3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
6TA6	ANTIMICROBIAL PROTEIN	10/29/19	MexAB assembly of the Pseudomonas MexAB-OprM efflux pump reconstituted in nanodiscs	Pseudomonas aeruginosa	3.2	ELECTRON MICROSCOPY	99.4
6IOK	MEMBRANE PROTEIN	10/30/18	Cryo-EM structure of multidrug efflux pump MexAB-OprM (0 degree state)	Pseudomonas aeruginosa PAO1	3.64	ELECTRON MICROSCOPY	99.4
6IOL	MEMBRANE PROTEIN	10/30/18	Cryo-EM structure of multidrug efflux pump MexAB-OprM (60 degree state)	Pseudomonas aeruginosa; Pseudomonas aeruginosa PAO1	3.76	ELECTRON MICROSCOPY	99.4
2V50	MEMBRANE PROTEIN	10/01/08	The Missing Part of the Bacterial MexAB-OprM System: Structural determination of the Multidrug Exporter MexB	PSEUDOMONAS AERUGINOSA PA01	3	X-RAY DIFFRACTION	99.4
3W9I	MEMBRANE PROTEIN	04/04/13	Structural basis for the inhibition of bacterial multidrug exporters	Pseudomonas aeruginosa	2.71	X-RAY DIFFRACTION	99.4
6TA5	ANTIMICROBIAL PROTEIN	10/29/19	OprM-MexA complex from the MexAB-OprM Pseudomonas aeruginosa whole assembly reconstituted in nanodiscs	Pseudomonas aeruginosa	3.2	ELECTRON MICROSCOPY	99.4
6T7S	ANTIMICROBIAL PROTEIN	10/23/19	MexB structure solved by cryo-EM in nanodisc in absence of its protein partners	Pseudomonas aeruginosa	4.5	ELECTRON MICROSCOPY	99.4

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG000417 (2093 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA2G_04342 Search term: multidrug transporter

Human Homologs

References