Pseudomonas aeruginosa PAO1, PA0106 (coxA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA0106
Name
coxA
Synonym: coI
Replicon chromosome
Genomic location 128512 - 130104 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_248796.1
GI 15595304
Affymetrix PA0106_coxA_at
Entrez 881877
GenBank AAG03496.1
INSDC AAG03496.1
NCBI Locus Tag PA0106
protein_id(GenBank) gb|AAG03496.1|AE004449_5|gnl|PseudoCAP|PA0106
TIGR NTL03PA00107
UniParc UPI00000C4F3B
UniProtKB Acc Q9I726
UniProtKB ID Q9I726_PSEAE
UniRef100 UniRef100_W0YJJ2
UniRef50 UniRef50_T2MHZ6
UniRef90 UniRef90_G8PXA8

Product

Feature Type CDS
Coding Frame 1
Product Name
cytochrome c oxidase, subunit I
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 1.00
Kyte-Doolittle Hydrophobicity Value 0.750
Molecular Weight (kDa) 58.8
Isoelectric Point (pI) 7.12

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 2
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold Protein Structure Database

Available for P. aeruginosa PAO1.

View predicted 3D structure in AlphaFold DB

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 436 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000104 (1031 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0106
Search term: coxA

Human Homologs

Ensembl 107, assembly GRCh38.p13
mitochondrially encoded cytochrome c oxidase I [Source:HGNC Symbol;Acc:HGNC:7419]
E-value: 1.5e-136
Percent Identity: 49.0

References

Cytochrome aa3 gene regulation in members of the family Rhizobiaceae: comparison of copper and oxygen effects in Bradyrhizobium japonicum and Rhizobium tropici.
Gabel C, Bittinger MA, Maier RJ
Appl. Environ. Microbiol. 1994 Jan;60(1):141-8
PubMed ID: 8117073