Pseudomonas aeruginosa PAO1, PA0357 (mutM)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006281 DNA repair
IGI
Inferred from Genetic Interaction 		ECO:0000316
genetic interaction evidence used in manual assertion		 12445642 Reviewed by curator
Molecular Function GO:0016787 hydrolase activity
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 12445642 Reviewed by curator
Biological Process GO:0006281 DNA repair
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 12445642 Reviewed by curator
Molecular Function GO:0003676 nucleic acid binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF46946
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006281 DNA repair
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00103
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003684 damaged DNA binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM01232
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00103
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008270 zinc ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM01232
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM01232
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0019104 DNA N-glycosylase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00898
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM01232
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006284 base-excision repair
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM01232
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

DNA replication, recombination, modification and repair Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae03410 Base excision repair 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SMART SM00898 Fapy_DNA_glyco_2 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain 2 116 1.5E-55
SUPERFAMILY SSF81624 N-terminal domain of MutM-like DNA repair proteins IPR035937 MutM-like, N-terminal 2 135 1.15E-40
FunFam G3DSA:1.10.8.50:FF:000003 Formamidopyrimidine-DNA glycosylase - - 132 270 3.4E-49
FunFam G3DSA:3.20.190.10:FF:000001 Formamidopyrimidine-DNA glycosylase - - 2 129 3.4E-48
Pfam PF01149 Formamidopyrimidine-DNA glycosylase N-terminal domain IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain 1 115 5.6E-33
SMART SM01232 H2TH_2 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding 130 222 6.8E-46
PANTHER PTHR22993 FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE - - 1 270 7.6E-48
Gene3D G3DSA:1.10.8.50 - - - 132 270 9.3E-44
SUPERFAMILY SSF57716 Glucocorticoid receptor-like (DNA-binding domain) - - 218 269 1.17E-16
CDD cd08966 EcFpg-like_N - - 2 117 4.04265E-53
Gene3D G3DSA:3.20.190.10 - IPR035937 MutM-like, N-terminal 2 128 5.4E-40
Pfam PF06831 Formamidopyrimidine-DNA glycosylase H2TH domain IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding 130 220 4.7E-25
NCBIfam TIGR00577 JCVI: DNA-formamidopyrimidine glycosylase IPR020629 Formamidopyrimidine-DNA glycosylase 1 269 3.9E-91
Hamap MF_00103 Formamidopyrimidine-DNA glycosylase [mutM]. IPR020629 Formamidopyrimidine-DNA glycosylase 1 270 44.768784
SUPERFAMILY SSF46946 S13-like H2TH domain IPR010979 Small ribosomal subunit protein uS13-like, H2TH 131 222 1.09E-27
Pfam PF06827 Zinc finger found in FPG and IleRS IPR010663 Zinc finger, FPG/IleRS-type 242 269 1.4E-8

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.