Pseudomonas aeruginosa PAO1, PA0517 (nirC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0517
Name
nirC
Replicon chromosome
Genomic location 577673 - 578032 (- strand)

Cross-References

RefSeq NP_249208.1
GI 15595714
Affymetrix PA0517_nirC_at
Entrez 879462
GenBank AAG03906.1
INSDC AAG03906.1
NCBI Locus Tag PA0517
protein_id(GenBank) gb|AAG03906.1|AE004488_10|gnl|PseudoCAP|PA0517
TIGR NTL03PA00518
UniParc UPI00001301AB
UniProtKB Acc Q51479
UniProtKB ID NIRC_PSEAE
UniRef100 UniRef100_Q51479
UniRef50 UniRef50_Q51479
UniRef90 UniRef90_Q51479

Product

Feature Type CDS
Coding Frame 1
Product Name
probable c-type cytochrome precursor
Product Name Confidence: Class 3
Synonyms Heme d1 biosynthesis protein NirC
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.14
Kyte-Doolittle Hydrophobicity Value -0.087
Molecular Weight (kDa) 12.8
Isoelectric Point (pI) 6.50

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 1
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6TP9 ELECTRON TRANSPORT 12/12/19 c-type cytochrome NirC Pseudomonas aeruginosa PAO1 2.19 X-RAY DIFFRACTION 96.7

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 37 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000501 (351 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0517
Search term: nirC

Human Homologs

References

Isolation, sequencing and mutational analysis of a gene cluster involved in nitrite reduction in Paracoccus denitrificans.
de Boer AP, Reijnders WN, Kuenen JG, Stouthamer AH, van Spanning RJ
Antonie Van Leeuwenhoek 1994;66(1-3):111-27
PubMed ID: 7747927