Pseudomonas aeruginosa PAO1, PA0927 (ldhA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0051287 NAD binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02826
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00389
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Energy metabolism Other PAO1 genes in this class
Central intermediary metabolism Other PAO1 genes in this class
Carbon compound catabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00620 Pyruvate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc FERMENTATION-PWY mixed acid fermentation 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCAP Pyruvate metabolism ECO:0000037
not_recorded
PseudoCyc P122-PWY heterolactic fermentation 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01120 Microbial metabolism in diverse environments 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain 110 297 3.8E-60
SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains IPR036291 NAD(P)-binding domain superfamily 102 298 1.84E-60
Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 3 327 1.8E-32
FunFam G3DSA:3.40.50.720:FF:000050 D-lactate dehydrogenase - - 102 297 2.2E-98
Gene3D G3DSA:3.40.50.720 - - - 102 297 0.0
Gene3D G3DSA:3.40.50.720 - - - 6 318 0.0
SUPERFAMILY SSF52283 Formate/glycerate dehydrogenase catalytic domain-like - - 2 134 5.1E-38
CDD cd12183 LDH_like_2 - - 1 323 0.0
PANTHER PTHR43026 2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED - - 1 323 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.