Pseudomonas aeruginosa PAO1, PA0945 (purM)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd02196
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006189 'de novo' IMP biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd02196
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Nucleotide biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc PWY-6122 5-aminoimidazole ribonucleotide biosynthesis II 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Purine metabolism ECO:0000037
not_recorded
PseudoCyc PRPP-PWY superpathway of histidine, purine, and pyrimidine biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00230 Purine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc DENOVOPURINE2-PWY superpathway of purine nucleotides de novo biosynthesis II 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
NCBIfam TIGR00878 JCVI: phosphoribosylformylglycinamidine cyclo-ligase IPR004733 Phosphoribosylformylglycinamidine cyclo-ligase 8 336 0.0
FunFam G3DSA:3.90.650.10:FF:000001 Phosphoribosylformylglycinamidine cyclo-ligase - - 172 348 1.1E-77
FunFam G3DSA:3.30.1330.10:FF:000001 Phosphoribosylformylglycinamidine cyclo-ligase - - 7 171 3.1E-82
Gene3D G3DSA:3.30.1330.10 - IPR036921 PurM-like, N-terminal domain superfamily 7 171 2.5E-69
Pfam PF00586 AIR synthase related protein, N-terminal domain IPR016188 PurM-like, N-terminal domain 62 165 8.8E-18
CDD cd02196 PurM IPR004733 Phosphoribosylformylglycinamidine cyclo-ligase 41 336 0.0
Pfam PF02769 AIR synthase related protein, C-terminal domain IPR010918 PurM-like, C-terminal domain 177 337 1.8E-39
PANTHER PTHR10520 TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED IPR004733 Phosphoribosylformylglycinamidine cyclo-ligase 4 351 0.0
Gene3D G3DSA:3.90.650.10 - IPR036676 PurM-like, C-terminal domain superfamily 172 353 2.3E-64
SUPERFAMILY SSF55326 PurM N-terminal domain-like IPR036921 PurM-like, N-terminal domain superfamily 8 171 2.09E-51
Hamap MF_00741 Phosphoribosylformylglycinamidine cyclo-ligase [purM]. IPR004733 Phosphoribosylformylglycinamidine cyclo-ligase 8 347 45.639286
SUPERFAMILY SSF56042 PurM C-terminal domain-like IPR036676 PurM-like, C-terminal domain superfamily 172 338 7.03E-62

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.