Pseudomonas aeruginosa PAO1, PA2480 (dsbS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2480
Name
dsbS
Replicon chromosome
Genomic location 2798412 - 2799734 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Comment DsbRS directly regulates the expression of the dsbDEG and dsbRS operons [doi.org/10.1016/j.scib.2021.03.003]

Cross-References

RefSeq NP_251170.1
GI 15597676
Affymetrix PA2480_at
Entrez 882195
GenBank AAG05868.1
INSDC AAG05868.1
NCBI Locus Tag PA2480
protein_id(GenBank) gb|AAG05868.1|AE004675_9|gnl|PseudoCAP|PA2480
TIGR NTL03PA02480
UniParc UPI00000C56F6
UniProtKB Acc Q9I102
UniProtKB ID Q9I102_PSEAE
UniRef100 UniRef100_W0YRC0
UniRef50 UniRef50_Q4K911
UniRef90 UniRef90_A6V4Y3

Product

Feature Type CDS
Coding Frame 1
Product Name
Dsb-associated Sensor, DsbS
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.27
Kyte-Doolittle Hydrophobicity Value -0.040
Molecular Weight (kDa) 47.7
Isoelectric Point (pI) 6.79

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 593 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003073 (489 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2480
Search term: dsbS

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295