Pseudomonas aeruginosa PAO1, PA2492 (mexT)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest |
| Locus Tag |
PA2492
|
| Name |
mexT
|
| Replicon | chromosome |
| Genomic location | 2807469 - 2808512 (+ strand) |
| Transposon Mutants | 5 transposon mutants in PAO1 |
| Transposon Mutants in orthologs | 4 transposon mutants in orthologs |
| Comment | Contains an 8_bp insertion at 2807703-2807710 which is the result of a duplication of the preceding 8_bp GGCCAGCC sequence at 2807695-2807702. When translated from this start codon, premature termination occurs at 2807857-2807859 and a MexT polypeptide of 89 amino acids is encoded (PMID:31859619). |
| Comment | PAO1 strains containing the 8_bp insertion are unable to express MexEF-OprN due to a non-functional MexT(PMID: 11040437) |
Cross-References
| RefSeq | |
| GI | |
| Affymetrix | PA2492_mexT_at |
| Entrez | 880417 |
| GenBank | AAG05880.1 |
| NCBI Locus Tag | PA2492 |
| protein_id(GenBank) | gb|AAG05880.1|AE004676_12|gnl|PseudoCAP|PA2492 |
| TIGR | NTL03PA02492 |
| UniProtKB Acc | Q9I0Z0 |
| UniProtKB ID | Q9I0Z0_PSEAE |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
transcriptional regulator MexT
|
| Synonyms | |
| Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
| Charge (pH 7) | |
| Kyte-Doolittle Hydrophobicity Value | |
| Molecular Weight (kDa) | |
| Isoelectric Point (pI) |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold Protein Structure Database
Available for P. aeruginosa PAO1.
| View predicted 3D structure in AlphaFold DB |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 185 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG001179 (1988 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PA2492
Search term: mexT
Search term: transcriptional regulator MexT
|
Human Homologs
References
|
Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa.
Köhler T, Michéa-Hamzehpour M, Henze U, Gotoh N, Curty LK, Pechère JC
Mol. Microbiol. 1997 Jan;23(2):345-54
PubMed ID: 9044268
|
|
MexT regulates the type III secretion system through MexS and PtrC in Pseudomonas aeruginosa.
Jin Y, Yang H, Qiao M, Jin S
J. Bacteriol. 2011 Jan;193(2):399-410
PubMed ID: 21075931
|
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<i>Pseudomonas aeruginosa mexT</i> is an indicator of PAO1 strain integrity.
LoVullo ED, Schweizer HP
J Med Microbiol 2020 Jan;69(1):139-145
PubMed ID: 31859619
|
|
Variation of the mexT gene, a regulator of the MexEF-oprN efflux pump expression in wild-type strains of Pseudomonas aeruginosa.
Maseda H, Saito K, Nakajima A, Nakae T
FEMS Microbiol Lett 2000 Nov 1;192(1):107-12
PubMed ID: 11040437
|