Pseudomonas aeruginosa PAO1, PA3159 (wbpA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0003954 NADH dehydrogenase activity
EXP
Inferred from Experiment 		ECO:0000269
experimental evidence used in manual assertion		 18621892 Reviewed by curator
Molecular Function GO:0047004 UDP-N-acetylglucosamine 6-dehydrogenase activity
EXP
Inferred from Experiment 		ECO:0000269
experimental evidence used in manual assertion		 15226302 Reviewed by curator
Biological Process GO:0000271 polysaccharide biosynthetic process
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 15226302 Reviewed by curator
Biological Process GO:0009243 O antigen biosynthetic process
EXP
Inferred from Experiment 		ECO:0000269
experimental evidence used in manual assertion		 18621892 Reviewed by curator
Biological Process GO:0000271 polysaccharide biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF500136
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000124
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0051287 NAD binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00984
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF500136
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Cell wall / LPS / capsule Other PAO1 genes in this class
Putative enzymes Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCAP Lipopolysaccharide biosynthesis ECO:0000037
not_recorded
PseudoCAP UDP-2,3-diacetamido-2,3-dideoxy-d-mannuronic acid biosynthesis pathway ECO:0000037
not_recorded
KEGG pae00520 Amino sugar and nucleotide sugar metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PANTHER PTHR43491 UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE IPR028359 UDP-N-acetyl-D-mannosamine/glucosamine dehydrogenase 9 432 0.0
PIRSF PIRSF500136 UDP_ManNAc_DH IPR028359 UDP-N-acetyl-D-mannosamine/glucosamine dehydrogenase 6 435 0.0
Pfam PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation 213 303 1.6E-28
Gene3D G3DSA:3.40.50.720 - - - 211 433 3.8E-58
SUPERFAMILY SSF52413 UDP-glucose/GDP-mannose dehydrogenase C-terminal domain IPR036220 UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily 317 427 2.09E-26
PIRSF PIRSF000124 UDPglc_GDPman_dh IPR017476 UDP-glucose/GDP-mannose dehydrogenase 17 435 5.1E-55
SMART SM00984 UDPG_MGDP_dh_C_a_2_a IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal 330 428 6.5E-31
Pfam PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal 18 192 3.6E-50
FunFam G3DSA:3.40.50.720:FF:000727 UDP-N-acetyl-D-glucosamine dehydrogenase - - 211 434 0.0
Pfam PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal 330 424 3.7E-21
NCBIfam TIGR03026 JCVI: nucleotide sugar dehydrogenase IPR017476 UDP-glucose/GDP-mannose dehydrogenase 18 423 8.3E-127
SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains IPR036291 NAD(P)-binding domain superfamily 18 206 4.79E-41
SUPERFAMILY SSF48179 6-phosphogluconate dehydrogenase C-terminal domain-like IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily 212 305 1.36E-29
Gene3D G3DSA:3.40.50.720 - - - 3 209 1.2E-53

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.