Pseudomonas aeruginosa PAO1, PA5418 (soxA)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Biological Process	GO:1901053	sarcosine catabolic process	IMP Inferred from Mutant Phenotype	ECO:0000015 mutant phenotype evidence	17951379	Reviewed by curator
Biological Process	GO:1901053	sarcosine catabolic process	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	17951383	Reviewed by curator
Molecular Function	GO:0008115	sarcosine oxidase activity	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	17951384	Reviewed by curator
Molecular Function	GO:0016491	oxidoreductase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PF07992	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0046653	tetrahydrofolate metabolic process	ISM Inferred from Sequence Model Term mapped from: InterPro:PIRSF037980	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0005515	protein binding	ISM Inferred from Sequence Model Term mapped from: InterPro:G3DSA:3.30.1360.120	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0008115	sarcosine oxidase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PIRSF037980	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Carbon compound catabolism Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae00260	Glycine, serine and threonine metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		glycine betaine catabolism		ECO:0000037 not_recorded
PseudoCyc	CRNFORCAT-PWY	creatinine degradation I	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
PRINTS	PR00469	Pyridine nucleotide disulphide reductase class-II signature	-	-	459	477	2.8E-10
NCBIfam	TIGR01372	JCVI: sarcosine oxidase subunit alpha family protein	IPR006277	Sarcosine oxidase, alpha subunit	2	1004	0.0
Pfam	PF13510	2Fe-2S iron-sulfur cluster binding domain	-	-	17	102	3.0E-22
Pfam	PF01571	Aminomethyltransferase folate-binding domain	IPR006222	Aminomethyltransferase, folate-binding domain	619	884	1.4E-74
Pfam	PF17806	Sarcosine oxidase A3 domain	IPR041117	SoxA, A3 domain	521	604	1.2E-31
FunFam	G3DSA:3.30.1360.120:FF:000038	Sarcosine oxidase subunit alpha	-	-	614	1004	0.0
Gene3D	G3DSA:1.10.10.1100	-	IPR041854	BFD-like [2Fe-2S]-binding domain superfamily	527	585	2.6E-6
SUPERFAMILY	SSF51905	FAD/NAD(P)-binding domain	IPR036188	FAD/NAD(P)-binding domain superfamily	167	448	1.1E-33
Pfam	PF07992	Pyridine nucleotide-disulphide oxidoreductase	IPR023753	FAD/NAD(P)-binding domain	172	434	2.9E-12
PRINTS	PR00469	Pyridine nucleotide disulphide reductase class-II signature	-	-	284	292	2.8E-10
Gene3D	G3DSA:3.30.1360.120	Probable tRNA modification gtpase trme; domain 1	IPR027266	GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1	614	1004	3.2E-129
PIRSF	PIRSF037980	Sarcos_oxid_alpha	IPR006277	Sarcosine oxidase, alpha subunit	1	1004	0.0
Gene3D	G3DSA:3.50.50.60	-	IPR036188	FAD/NAD(P)-binding domain superfamily	167	317	8.0E-21
SUPERFAMILY	SSF103025	Folate-binding domain	-	-	613	895	1.4E-92
FunFam	G3DSA:3.50.50.60:FF:000476	Sarcosine oxidase subunit alpha	-	-	167	317	4.0E-101
PANTHER	PTHR43104	L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL	-	-	1	948	1.1E-72
SUPERFAMILY	SSF101790	Aminomethyltransferase beta-barrel domain	IPR029043	Glycine cleavage T-protein/YgfZ, C-terminal	906	1003	1.16E-17
Gene3D	G3DSA:3.10.20.440	-	IPR042204	2Fe-2S iron-sulfur cluster binding domain, N-terminal	10	104	6.6E-21
PRINTS	PR00368	FAD-dependent pyridine nucleotide reductase signature	-	-	173	192	4.5E-8
PRINTS	PR00469	Pyridine nucleotide disulphide reductase class-II signature	-	-	172	194	2.8E-10
PRINTS	PR00368	FAD-dependent pyridine nucleotide reductase signature	-	-	283	301	4.5E-8
Pfam	PF08669	Glycine cleavage T-protein C-terminal barrel domain	IPR013977	Glycine cleavage T-protein, C-terminal barrel domain	910	996	1.5E-19

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.