Pseudomonas aeruginosa PAO1, PA5425 (purK)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006163 purine nucleotide metabolic process
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Molecular Function GO:0004157 dihydropyrimidinase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0009117 nucleotide metabolic process
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Molecular Function GO:0005524 ATP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.30.1490.20
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004638 phosphoribosylaminoimidazole carboxylase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01928
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006189 'de novo' IMP biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01928
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Nucleotide biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00230 Purine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Purine metabolism ECO:0000037
not_recorded
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
FunFam G3DSA:3.30.1490.20:FF:000015 N5-carboxyaminoimidazole ribonucleotide synthase - - 102 175 1.7E-31
FunFam G3DSA:3.40.50.20:FF:000016 N5-carboxyaminoimidazole ribonucleotide synthase - - 1 101 3.8E-48
Hamap MF_01928 N5-carboxyaminoimidazole ribonucleotide synthase [purK]. IPR005875 Phosphoribosylaminoimidazole carboxylase, ATPase subunit 2 344 39.176777
Gene3D G3DSA:3.30.1490.20 - IPR013815 ATP-grasp fold, subdomain 1 102 175 2.6E-26
NCBIfam TIGR01161 JCVI: 5-(carboxyamino)imidazole ribonucleotide synthase IPR005875 Phosphoribosylaminoimidazole carboxylase, ATPase subunit 2 348 4.2E-108
PANTHER PTHR11609 PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7 - - 2 357 1.3E-109
Gene3D G3DSA:3.30.470.20 - - - 176 360 3.5E-62
SUPERFAMILY SSF51246 Rudiment single hybrid motif IPR011054 Rudiment single hybrid motif 297 356 2.35E-13
FunFam G3DSA:3.30.470.20:FF:000029 N5-carboxyaminoimidazole ribonucleotide synthase - - 176 359 1.4E-71
Gene3D G3DSA:3.40.50.20 - - - 1 101 7.7E-33
SUPERFAMILY SSF56059 Glutathione synthetase ATP-binding domain-like - - 97 292 2.47E-56
SUPERFAMILY SSF52440 PreATP-grasp domain IPR016185 Pre-ATP-grasp domain superfamily 2 94 2.45E-22
Pfam PF17769 Phosphoribosylaminoimidazole carboxylase C-terminal domain IPR040686 Phosphoribosylaminoimidazole carboxylase, C-terminal domain 298 349 1.7E-12
Pfam PF02222 ATP-grasp domain IPR003135 ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type 106 272 1.0E-57

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.