Pseudomonas aeruginosa PAO1, PA5443 (uvrD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006298 mismatch repair
IMP
Inferred from Mutant Phenotype
ECO:0000015
mutant phenotype evidence
11952911 Reviewed by curator
Molecular Function GO:0003678 DNA helicase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01075
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003677 DNA binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR11070
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0005524 ATP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00580
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016787 hydrolase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF13361
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0005737 cytoplasm
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01075
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006268 DNA unwinding involved in DNA replication
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01075
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Related to phage, transposon, or plasmid Other PAO1 genes in this class
DNA replication, recombination, modification and repair Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae03420 Nucleotide excision repair 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae03430 Mismatch repair 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
FunFam G3DSA:3.40.50.300:FF:001201 ATP-dependent DNA helicase UvrD2 - - 282 385 7.0E-34
Pfam PF13361 UvrD-like helicase C-terminal domain IPR014017 UvrD-like DNA helicase, C-terminal 279 618 2.3E-78
Gene3D G3DSA:1.10.486.10 PCRA; domain 4 - - 384 540 0.0
Gene3D G3DSA:3.40.50.300 - IPR027417 P-loop containing nucleoside triphosphate hydrolase 283 638 0.0
SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases IPR027417 P-loop containing nucleoside triphosphate hydrolase 9 644 0.0
CDD cd17932 DEXQc_UvrD - - 16 285 5.12281E-89
NCBIfam TIGR01075 JCVI: DNA helicase UvrD IPR005753 DNA helicase, ATP-dependent, UvrD type 8 726 0.0
PANTHER PTHR11070 UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER IPR000212 DNA helicase, UvrD/REP type 10 647 0.0
FunFam G3DSA:1.10.10.160:FF:000002 DNA helicase - - 116 189 2.2E-28
Gene3D G3DSA:1.10.10.160 - IPR013986 DExx box DNA helicase domain superfamily 116 189 1.1E-102
Pfam PF00580 UvrD/REP helicase N-terminal domain IPR014016 UvrD-like helicase, ATP-binding domain 12 273 6.8E-74
CDD cd18807 SF1_C_UvrD - - 287 616 6.05832E-31
Gene3D G3DSA:3.40.50.300 - IPR027417 P-loop containing nucleoside triphosphate hydrolase 12 275 1.1E-102
FunFam G3DSA:1.10.486.10:FF:000001 DNA helicase - - 384 540 1.1E-73

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.