Pseudomonas aeruginosa PAO1, PA5497 (nrdJa)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Molecular Function	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	15722359	Reviewed by curator
Molecular Function	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	ISM Inferred from Sequence Model Term mapped from: InterPro:cd02888	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0031419	cobalamin binding	ISM Inferred from Sequence Model Term mapped from: InterPro:cd02888	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0000166	nucleotide binding	ISM Inferred from Sequence Model Term mapped from: InterPro:cd02888	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Nucleotide biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
PseudoCAP		Pyrimidine metabolism		ECO:0000037 not_recorded
KEGG	pae00230	Purine metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae00240	Pyrimidine metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		Purine metabolism		ECO:0000037 not_recorded

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
PRINTS	PR01183	Ribonucleotide reductase large chain signature	IPR000788	Ribonucleotide reductase large subunit, C-terminal	374	397	2.6E-18
PANTHER	PTHR43371	VITAMIN B12-DEPENDENT RIBONUCLEOTIDE REDUCTASE	-	-	15	725	0.0
Gene3D	G3DSA:3.20.70.20	-	-	-	14	672	0.0
Pfam	PF02867	Ribonucleotide reductase, barrel domain	IPR000788	Ribonucleotide reductase large subunit, C-terminal	123	669	0.0
PRINTS	PR01183	Ribonucleotide reductase large chain signature	IPR000788	Ribonucleotide reductase large subunit, C-terminal	197	216	2.6E-18
SUPERFAMILY	SSF51998	PFL-like glycyl radical enzymes	-	-	35	710	0.0
NCBIfam	TIGR02504	JCVI: adenosylcobalamin-dependent ribonucleoside-diphosphate reductase	IPR013344	Ribonucleotide reductase, adenosylcobalamin-dependent	43	678	0.0
CDD	cd02888	RNR_II_dimer	IPR013344	Ribonucleotide reductase, adenosylcobalamin-dependent	95	671	0.0
PRINTS	PR01183	Ribonucleotide reductase large chain signature	IPR000788	Ribonucleotide reductase large subunit, C-terminal	412	434	2.6E-18
PRINTS	PR01183	Ribonucleotide reductase large chain signature	IPR000788	Ribonucleotide reductase large subunit, C-terminal	440	463	2.6E-18
PRINTS	PR01183	Ribonucleotide reductase large chain signature	IPR000788	Ribonucleotide reductase large subunit, C-terminal	528	555	2.6E-18
FunFam	G3DSA:3.20.70.20:FF:000040	Vitamin B12-dependent ribonucleotide reductase	-	-	14	672	0.0
PRINTS	PR01183	Ribonucleotide reductase large chain signature	IPR000788	Ribonucleotide reductase large subunit, C-terminal	336	347	2.6E-18

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.