Pseudomonas aeruginosa PAO1, PA5541 (pyrQ)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Molecular Function	GO:0004151	dihydroorotase activity	IMP Inferred from Mutant Phenotype	ECO:0000015 mutant phenotype evidence	15278241	Reviewed by curator
Biological Process	GO:0006221	pyrimidine nucleotide biosynthetic process	IMP Inferred from Mutant Phenotype	ECO:0000015 mutant phenotype evidence	15278241	Reviewed by curator
Molecular Function	GO:0016787	hydrolase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PF01979	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	ISM Inferred from Sequence Model Term mapped from: InterPro:SSF51338	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Nucleotide biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
PseudoCyc	PRPP-PWY	superpathway of histidine, purine, and pyrimidine biosynthesis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCyc	PWY-5686	UMP biosynthesis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCyc	PWY0-162	superpathway of pyrimidine ribonucleotides de novo biosynthesis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCAP		Pyrimidine metabolism		ECO:0000037 not_recorded
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae00240	Pyrimidine metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
SUPERFAMILY	SSF51338	Composite domain of metallo-dependent hydrolases	IPR011059	Metal-dependent hydrolase, composite domain superfamily	1	433	6.81E-25
Gene3D	G3DSA:3.20.20.140	-	-	-	56	412	2.6E-127
SUPERFAMILY	SSF51556	Metallo-dependent hydrolases	IPR032466	Metal-dependent hydrolase	55	371	2.96E-91
Pfam	PF01979	Amidohydrolase family	IPR006680	Amidohydrolase-related	231	425	6.8E-6
PANTHER	PTHR43668	ALLANTOINASE	-	-	1	431	2.2E-83
CDD	cd01318	DHOase_IIb	-	-	49	423	0.0
Gene3D	G3DSA:2.30.40.10	Urease, subunit C, domain 1	IPR011059	Metal-dependent hydrolase, composite domain superfamily	6	428	2.6E-127

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.