Pseudomonas aeruginosa PAO1, PA0025 (aroE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0025
Name
aroE
Replicon chromosome
Genomic location 26711 - 27535 (+ strand)

Cross-References

RefSeq NP_248715.1
GI 15595223
Affymetrix PA0025_aroE_at
DNASU PaCD00006014
Entrez 880894
GenBank AAG03415.1
INSDC AAG03415.1
NCBI Locus Tag PA0025
protein_id(GenBank) gb|AAG03415.1|AE004442_2|gnl|PseudoCAP|PA0025
TIGR NTL03PA00026
UniParc UPI0000125FF0
UniProtKB Acc P43904
UniProtKB ID AROE_PSEAE
UniRef100 UniRef100_P43904
UniRef50 UniRef50_A1S1K8
UniRef90 UniRef90_P43904

Product

Feature Type CDS
Coding Frame 1
Product Name
shikimate dehydrogenase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -3.39
Kyte-Doolittle Hydrophobicity Value -0.023
Molecular Weight (kDa) 29.5
Isoelectric Point (pI) 5.46

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 607 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000025 (538 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0025
Search term: aroE

Human Homologs

References

Sequencing and overexpression of the Escherichia coli aroE gene encoding shikimate dehydrogenase.
Anton IA, Coggins JR
Biochem J 1988 Jan 15;249(2):319-26
PubMed ID: 3277621