Pseudomonas aeruginosa UCBPP-PA14, PA14_01030 (hcp1)

Cytoplasmic Membrane
Outer Membrane
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
Locus Tag
Replicon chromosome
Genomic location 101003 - 101491 (+ strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 4 transposon mutants in orthologs
CommentHcp Secretion Island-I-encoded type VI secretion system (H1-T6SS)


RefSeq YP_788242.1
GI 116053805
Entrez 4383503
INSDC ABJ15041.1
NCBI Locus Tag PA14_01030
UniParc UPI00000C4F26
UniProtKB Acc Q02UZ4
UniRef100 UniRef100_Q9I747
UniRef50 UniRef50_Q9I747
UniRef90 UniRef90_Q9I747


Feature Type CDS
Coding Frame 1
Product Name
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) -0.32
Kyte-Doolittle Hydrophobicity Value -0.415
Molecular Weight (kDa) 17.4
Isoelectric Point (pI) 6.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4KSR PROTEIN TRANSPORT 05/17/13 Crystal Structure of the Vibrio cholerae ATPase GspE Hexamer Pseudomonas aeruginosa; Vibrio cholerae O1 4.2 X-RAY DIFFRACTION 100.0
1Y12 structural genomics, unknown function 11/16/04 Structure of a hemolysin-coregulated protein from Pseudomonas aeruginosa Pseudomonas aeruginosa PAO1 1.95 X-RAY DIFFRACTION 100.0
4KSS PROTEIN TRANSPORT 05/17/13 Crystal Structure of Vibrio cholerae ATPase GspsE Hexamer Pseudomonas aeruginosa; Vibrio cholerae O1 7.58 X-RAY DIFFRACTION 100.0
7O42 MEMBRANE PROTEIN 04/04/21 TrwK/VirB4unbound trimer of dimers complex (with Hcp1) from the R388 type IV secretion system determined by cryo-EM. Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1); Salmonella dublin 4.1 ELECTRON MICROSCOPY 98.1
6AP1 TRANSPORT PROTEIN 08/16/17 Vps4p-Vta1p complex with peptide binding to the central pore of Vps4p Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1); Saccharomyces cerevisiae (strain ATCC 204508 / S288c); SYNTHETIC CONSTRUCT 3.2 ELECTRON MICROSCOPY 99.4

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 75 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000084 (750 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA14_01030
Search term: hcp1
Search term: Hcp1

Human Homologs


RsmA and AmrZ orchestrate the assembly of all three type VI secretion systems in Pseudomonas aeruginosa.
Allsopp LP, Wood TE, Howard SA, Maggiorelli F, Nolan LM, Wettstadt S, Filloux A
Proc Natl Acad Sci U S A 2017 Jul 18;114(29):7707-7712
PubMed ID: 28673999