Pseudomonas aeruginosa UCBPP-PA14, PA14_04580 (folA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0050661 NADP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000194
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004146 dihydrofolate reductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00186
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0046654 tetrahydrofolate biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00186
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006545 glycine biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000194
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other UCBPP-PA14 genes in this class
Central intermediary metabolism Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pau00670 One carbon pool by folate 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00790 Folate biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.40.430.10 Dihydrofolate Reductase, subunit A IPR024072 Dihydrofolate reductase-like domain superfamily 4 168 6.9E-56
PRINTS PR00070 Dihydrofolate reductase signature - - 30 38 6.8E-16
PRINTS PR00070 Dihydrofolate reductase signature - - 43 54 6.8E-16
Pfam PF00186 Dihydrofolate reductase IPR001796 Dihydrofolate reductase domain 5 167 1.2E-54
SUPERFAMILY SSF53597 Dihydrofolate reductase-like IPR024072 Dihydrofolate reductase-like domain superfamily 4 168 2.11E-55
PRINTS PR00070 Dihydrofolate reductase signature - - 16 26 6.8E-16
FunFam G3DSA:3.40.430.10:FF:000001 Dihydrofolate reductase - - 3 168 3.3E-61
PIRSF PIRSF000194 DHFR IPR012259 Dihydrofolate reductase 1 168 1.6E-58
PRINTS PR00070 Dihydrofolate reductase signature - - 100 114 6.8E-16
CDD cd00209 DHFR IPR001796 Dihydrofolate reductase domain 5 151 1.36152E-69
PANTHER PTHR48069 DIHYDROFOLATE REDUCTASE IPR012259 Dihydrofolate reductase 5 166 4.1E-37

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.