Pseudomonas aeruginosa UCBPP-PA14, PA14_04630 (ilvD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004160 dihydroxy-acid dehydratase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00012
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PS00886
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009082 branched-chain amino acid biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00012
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other UCBPP-PA14 genes in this class
Biosynthesis of cofactors, prosthetic groups and carriers Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pau01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00290 Valine, leucine and isoleucine biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01210 2-Oxocarboxylic acid metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00770 Pantothenate and CoA biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
ProSitePatterns PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. IPR020558 Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site 507 518 -
Hamap MF_00012 Dihydroxy-acid dehydratase [ilvD]. IPR004404 Dihydroxy-acid dehydratase 4 606 44.984
Gene3D G3DSA:3.50.30.80 IPR042096 Dihydroxy-acid dehydratase, C-terminal 419 571 6.8E-54
ProSitePatterns PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. IPR020558 Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site 122 132 -
SUPERFAMILY SSF52016 419 606 1.33E-59
TIGRFAM TIGR00110 ilvD: dihydroxy-acid dehydratase IPR004404 Dihydroxy-acid dehydratase 18 606 0.0
Pfam PF00920 Dehydratase family IPR000581 Dihydroxy-acid/6-phosphogluconate dehydratase 34 603 0.0
SUPERFAMILY SSF143975 IPR037237 IlvD/EDD, N-terminal domain 3 418 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.