Pseudomonas aeruginosa UCBPP-PA14, PA14_55610 (dnaE2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0003887 DNA-directed DNA polymerase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01902
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006260 DNA replication
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF07733
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02811
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008408 3'-5' exonuclease activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF07733
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Putative enzymes Other UCBPP-PA14 genes in this class
DNA replication, recombination, modification and repair Other UCBPP-PA14 genes in this class

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
FunFam G3DSA:1.10.150.870:FF:000002 Error-prone DNA polymerase - - 758 850 4.6E-30
Gene3D G3DSA:1.10.150.870 - - - 762 850 2.1E-8
SMART SM00481 npolultra IPR003141 Polymerase/histidinol phosphatase, N-terminal 12 79 4.1E-10
NCBIfam TIGR00594 JCVI: DNA polymerase III subunit alpha IPR004805 Error-prone DNA polymerase/DNA polymerase III subunit alpha DnaE/PolC 12 975 0.0
CDD cd04485 DnaE_OBF - - 942 1029 2.51825E-18
Pfam PF14579 Helix-hairpin-helix motif IPR029460 DNA polymerase, helix-hairpin-helix motif 774 862 1.0E-21
SUPERFAMILY SSF89550 PHP domain-like IPR016195 Polymerase/histidinol phosphatase-like 11 192 1.24E-10
Gene3D G3DSA:3.20.20.140 - - - 5 252 5.7E-64
PANTHER PTHR32294 DNA POLYMERASE III SUBUNIT ALPHA IPR004805 Error-prone DNA polymerase/DNA polymerase III subunit alpha DnaE/PolC 8 1019 0.0
Pfam PF07733 Bacterial DNA polymerase III alpha NTPase domain IPR011708 Bacterial DNA polymerase III, alpha subunit, NTPase domain 275 529 1.3E-82
CDD cd07434 PHP_PolIIIA_DnaE2 - - 11 262 3.83648E-129
Pfam PF02811 PHP domain IPR004013 PHP domain 13 128 1.4E-15
Hamap MF_01902 Error-prone DNA polymerase [dnaE2]. IPR023073 DNA polymerase, error-prone 11 1031 14.004007
Pfam PF17657 Bacterial DNA polymerase III alpha subunit finger domain IPR040982 DNA polymerase III alpha subunit finger domain 532 699 3.5E-58

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.