Pseudomonas aeruginosa UCBPP-PA14, PA14_72490 (polA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006261 DNA-dependent DNA replication
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00868
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006139 nucleobase-containing compound metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00474
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003887 DNA-directed DNA polymerase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00868
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd09898
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003677 DNA binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd09898
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006260 DNA replication
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00482
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003676 nucleic acid binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00474
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008408 3'-5' exonuclease activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00474
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

DNA replication, recombination, modification and repair Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pau01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00230 Purine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00240 Pyrimidine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau03420 Nucleotide excision repair 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau03030 DNA replication 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau03440 Homologous recombination 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau03410 Base excision repair 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
FunFam G3DSA:3.30.420.10:FF:000026 DNA polymerase I - - 309 526 1.3E-97
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 798 809 1.0E-77
SUPERFAMILY SSF56672 DNA/RNA polymerases IPR043502 DNA/RNA polymerase superfamily 506 913 0.0
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 739 764 1.0E-77
Gene3D G3DSA:1.20.1060.10 Taq DNA Polymerase; Chain T, domain 4 - - 527 643 1.1E-36
Gene3D G3DSA:3.30.70.370 - - - 649 909 1.2E-114
SUPERFAMILY SSF53098 Ribonuclease H-like IPR012337 Ribonuclease H-like superfamily 311 501 3.8E-55
FunFam G3DSA:1.10.150.20:FF:000002 DNA polymerase I - - 694 837 1.9E-60
SMART SM00475 53exo3 IPR002421 5'-3' exonuclease 4 266 4.6E-116
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 776 787 1.0E-77
SMART SM00279 HhH_4 IPR008918 Helix-hairpin-helix motif, class 2 170 205 6.1E-12
FunFam G3DSA:1.20.1060.10:FF:000001 DNA polymerase I - - 527 643 2.9E-40
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 860 873 1.0E-77
CDD cd08637 DNA_pol_A_pol_I_C - - 532 910 0.0
Gene3D G3DSA:1.10.150.20 - - - 694 837 1.2E-114
NCBIfam TIGR00593 JCVI: DNA polymerase I IPR018320 DNA polymerase 1 6 913 0.0
CDD cd09859 PIN_53EXO - - 8 164 2.77825E-78
Gene3D G3DSA:3.40.50.1010 - - - 1 169 7.4E-54
Gene3D G3DSA:3.30.420.10 - IPR036397 Ribonuclease H superfamily 309 526 9.9E-74
Pfam PF00476 DNA polymerase family A IPR001098 DNA-directed DNA polymerase, family A, palm domain 538 911 0.0
CDD cd09898 H3TH_53EXO IPR020045 DNA polymerase I-like, H3TH domain 170 250 1.46374E-24
SUPERFAMILY SSF47807 5' to 3' exonuclease, C-terminal subdomain IPR036279 5'-3' exonuclease, C-terminal domain superfamily 168 288 1.14E-28
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 640 662 1.0E-77
FunFam G3DSA:3.40.50.1010:FF:000001 DNA polymerase I - - 1 169 5.5E-71
SMART SM00474 35exoneu6 IPR002562 3'-5' exonuclease domain 312 501 1.1E-36
SMART SM00482 polaultra3 IPR001098 DNA-directed DNA polymerase, family A, palm domain 671 877 1.5E-118
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 685 708 1.0E-77
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 830 846 1.0E-77
PANTHER PTHR10133 DNA POLYMERASE I IPR002298 DNA polymerase A 308 913 0.0
Pfam PF02739 5'-3' exonuclease, N-terminal resolvase-like domain IPR020046 5'-3' exonuclease, alpha-helical arch, N-terminal 6 167 2.1E-51
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 715 728 1.0E-77
FunFam G3DSA:1.10.150.20:FF:000003 DNA polymerase I - - 170 265 8.2E-27
Pfam PF01612 3'-5' exonuclease IPR002562 3'-5' exonuclease domain 313 501 1.0E-37
Gene3D G3DSA:1.10.150.20 - - - 170 264 8.2E-26
CDD cd06139 DNA_polA_I_Ecoli_like_exo - - 327 523 5.52605E-98
PRINTS PR00868 DNA-polymerase family A (pol I) signature IPR002298 DNA polymerase A 663 678 1.0E-77
Pfam PF01367 5'-3' exonuclease, C-terminal SAM fold IPR020045 DNA polymerase I-like, H3TH domain 168 269 4.5E-27
SUPERFAMILY SSF88723 PIN domain-like IPR029060 PIN-like domain superfamily 5 167 8.41E-53

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.