Pseudomonas aeruginosa PAO1, PA0686 (hxcR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0686
Name
hxcR
Replicon chromosome
Genomic location 744333 - 745742 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 4 transposon mutants in orthologs
CommentBelongs to the GspE family (general secretory pathway). The hxc gene cluster is under phosphate regulation. Hxc proteins are involved in alkaline phosphatase secretion.

Cross-References

RefSeq NP_249377.1
GI 15595883
Affymetrix PA0686_at
Entrez 880808
GenBank AAG04075.1
INSDC AAG04075.1
NCBI Locus Tag PA0686
protein_id(GenBank) gb|AAG04075.1|AE004503_13|gnl|PseudoCAP|PA0686
TIGR NTL03PA00687
UniParc UPI00000C50FF
UniProtKB Acc Q9I5N9
UniProtKB ID HXCR_PSEAE
UniRef100 UniRef100_Q9I5N9
UniRef50 UniRef50_Q9I5N9
UniRef90 UniRef90_Q9I5N9

Product

Feature Type CDS
Coding Frame 1
Product Name
HxcR
Product Name Confidence: Class 1
Synonyms probable type II secretion system protein
Evidence for Translation
Charge (pH 7) -8.21
Kyte-Doolittle Hydrophobicity Value -0.041
Molecular Weight (kDa) 51.0
Isoelectric Point (pI) 5.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 513 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000665 (786 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0686
Search term: hxcR
Search term: HxcR

Human Homologs

References

Assembly of XcpR in the cytoplasmic membrane is required for extracellular protein secretion in Pseudomonas aeruginosa.
Ball G, Chapon-Hervé V, Bleves S, Michel G, Bally M
J Bacteriol 1999 Jan;181(2):382-8
PubMed ID: 9882649
A novel type II secretion system in Pseudomonas aeruginosa.
Ball G, Durand E, Lazdunski A, Filloux A
Mol Microbiol 2002 Jan;43(2):475-85
PubMed ID: 11985723
Protein secretion in Pseudomonas aeruginosa: characterization of seven xcp genes and processing of secretory apparatus components by prepilin peptidase.
Bally M, Filloux A, Akrim M, Ball G, Lazdunski A, Tommassen J
Mol Microbiol 1992 May;6(9):1121-31
PubMed ID: 1588814