Pseudomonas aeruginosa PAO1, PA1068

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1068
Name
Replicon chromosome
Genomic location 1153637 - 1155547 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249759.1
GI 15596265
Affymetrix PA1068_at
Entrez 879652
GenBank AAG04457.1
INSDC AAG04457.1
NCBI Locus Tag PA1068
protein_id(GenBank) gb|AAG04457.1|AE004538_9|gnl|PseudoCAP|PA1068
TIGR NTL03PA01069
UniParc UPI00000C5236
UniProtKB Acc Q9I4Q6
UniProtKB ID Q9I4Q6_PSEAE
UniRef100 UniRef100_Q9I4Q6
UniRef50 UniRef50_B7LVF2
UniRef90 UniRef90_A0A038C8K8

Product

Feature Type CDS
Coding Frame 1
Product Name
probable heat shock protein (hsp90 family)
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -12.28
Kyte-Doolittle Hydrophobicity Value -0.289
Molecular Weight (kDa) 70.7
Isoelectric Point (pI) 5.65

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 403 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001030 (298 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1068

Human Homologs

Ensembl 110, assembly GRCh38.p14
TNF receptor associated protein 1 [Source:HGNC Symbol;Acc:HGNC:16264]
E-value: 3.2e-27
Percent Identity: 24.4
Ensembl 110, assembly GRCh38.p14
TNF receptor associated protein 1 [Source:HGNC Symbol;Acc:HGNC:16264]
E-value: 3.2e-27
Percent Identity: 24.4

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases.
Nadeau K, Das A, Walsh CT
J Biol Chem 1993 Jan 15;268(2):1479-87
PubMed ID: 8419347