Pseudomonas aeruginosa UCBPP-PA14, PA14_11690 (ppa)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_11690
Name
ppa
Replicon chromosome
Genomic location 1013172 - 1013699 (- strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq YP_789088.1
GI 116052068
EC Number 3.6.1.1
Entrez 4382040
INSDC ABJ13304.1
NCBI Locus Tag PA14_11690
UniParc UPI000012D84B
UniProtKB Acc Q02SJ8
UniProtKB ID Q02SJ8_PSEAB
UniRef100 UniRef100_Q9HWZ6
UniRef50 UniRef50_Q9HWZ6
UniRef90 UniRef90_Q9HWZ6

Product

Feature Type CDS
Coding Frame 1
Product Name
inorganic pyrophosphatase
Synonyms
Evidence for Translation
Charge (pH 7) -6.08
Kyte-Doolittle Hydrophobicity Value -0.142
Molecular Weight (kDa) 19.4
Isoelectric Point (pI) 4.86

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4XEL HYDROLASE 12/24/14 Crystal structure of Inorganic pyrophosphatase (PPase) from Pseudomonas aeruginosa Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) 2 X-RAY DIFFRACTION 100.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
N-(pyridin-3-ylmethyl)aniline DB06851 DrugBank 5.1.4 Q3JUV5 Inorganic pyrophosphatase 62.9 175 3.4e-59
5-amino-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile DB07291 DrugBank 5.1.4 Q3JUV5 Inorganic pyrophosphatase 62.9 175 3.4e-59

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 482 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001653 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_11690
Search term: ppa

Human Homologs

References

No references are associated with this feature.