Pseudomonas aeruginosa UCBPP-PA14, PA14_54000 (prpD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_54000
Name
prpD
Replicon chromosome
Genomic location 4788579 - 4790063 (+ strand)
Transposon Mutants 2 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq YP_792490.1
GI 116048710
EC Number 4.2.1.79
Entrez 4381659
INSDC ABJ09946.1
NCBI Locus Tag PA14_54000
UniParc UPI000045D040
UniProtKB Acc Q02HU6
UniProtKB ID Q02HU6_PSEAB
UniRef100 UniRef100_Q02HU6
UniRef50 UniRef50_P77243
UniRef90 UniRef90_A6VAI3

Product

Feature Type CDS
Coding Frame 1
Product Name
2-methylcitrate dehydratase
Synonyms
Evidence for Translation
Charge (pH 7) -3.90
Kyte-Doolittle Hydrophobicity Value -0.137
Molecular Weight (kDa) 54.9
Isoelectric Point (pI) 6.60

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6S62 ISOMERASE 07/02/19 Crystal structure of 2-methylcitrate dehydratase (PrpD) from Pseudomonas aeruginosa in apo form. Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.36 X-RAY DIFFRACTION 99.4

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 150 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000765 (441 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_54000
Search term: prpD

Human Homologs

References

No references are associated with this feature.